Fenbendazole – A Suprise From A Generic Dewormer

I was doing some general purpose digging into anti-viral agents (where I eneded up ordering another jug of ivermectin) and then looked on the bookcase shelf. There was an almost empty tube of Fenbendazole worming paste. This one was intended for horses. I’d originally gotten it some years back as I was franticly trying to find a cure for head tilt in my rabbits. ( I did, it worked ). Why did I do that? Because the Vet was not encouraging and most folks took the path of “rabbits are cheap just get another one”. Treatment was not clear or easily available.

So, OK, after that I kept a tube of it around for deworming and any recurance of head tilt in a bunny. But now the bunnies are gone. Yet I’d not tossed it out.

I got to wondering about the active ingredient Fenbendazole. It, like Ivermectin (the other half of my bunny cure) has some broad activities. Mosty used to get rid of worms, but it does other things too.

https://en.wikipedia.org/wiki/Fenbendazole

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, and seals.

Drug interactions

Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered. Abortions in cattle and death in sheep have been reported after using these medications together. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.

Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis, and distal villi sloughing.

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species.
The LD50 in laboratory animals exceeds 10 g/kg when administered orally.

So you can get a good dose on the worms in the gut without too much being absorbed into the body. This is an apple flavored paste for horses. Rubbed on skin it does slowly soak in, but that’s not the intended mode. The biggest issues for non-worming uses is just getting it into the body.

So, OK, imagine my surprise when it turned up on a search for anti-virals and as used by some folks to treat cancers (and leading to the speculation that maybe more cancers are caused by viruses than originally thought…)

https://www.researchgate.net/publication/260343692_Effects_of_fenbendazole_and_vitamin_E_succinate_on_the_growth_and_survival_of_prostate_cancer_cells

We describe antitumor activities of vitamin E succinate (VES), an anti-oxidant and fenbendazole (FBZ), a commonly used veterinary anthelmintic. We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. Apoptosis was the likely mechanism for the observed effect. These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436308/

Abstract

In recent years, there has been a great deal of interest in proteasome inhibitors as a novel class of anticancer drugs. We report that fenbendazole (FZ) (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate) exhibits a potent growth-inhibitory activity against cancer cell lines but not normal cells. We show here, using fluorogenic substrates, that FZ treatment leads to the inhibition of proteasomal activity in the cells. Succinyl-Leu-Leu-Val-Tyr-methylcoumarinamide (MCA), benzyloxycarbonyl-Leu-Leu-Glu-7-amido-4-MCA, and t-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-MCA fluorescent derivatives were used to assess chymotrypsin-like, post-glutamyl peptidyl-hydrolyzing, and trypsin-like protease activities, respectively. Non-small cell lung cancer cells transiently transfected with an expression plasmid encoding pd1EGFP and treated with FZ showed an accumulation of the green fluorescent protein in the cells due to an increase in its half-life. A number of apoptosis regulatory proteins that are normally degraded by the ubiquitin-proteasome pathway like cyclins, p53, and IκBα were found to be accumulated in FZ-treated cells. In addition, FZ induced distinct ER stress-associated genes like GRP78, GADD153, ATF3, IRE1α, and NOXA in these cells. Thus, treatment of human NSCLC cells with fenbendazole induced endoplasmic reticulum stress, reactive oxygen species production, decreased mitochondrial membrane potential, and cytochrome c release that eventually led to cancer cell death. This is the first report to demonstrate the inhibition of proteasome function and induction of endoplasmic reticulum stress/reactive oxygen species-dependent apoptosis in human lung cancer cell lines by fenbendazole, which may represent a new class of anticancer agents showing selective toxicity against cancer cells.

Keywords: Anticancer Drug, Apoptosis, Cell Growth, ER Stress, p53, Proteasome, Reactive Oxygen Species (ROS)

https://www.nature.com/articles/s41598-018-30158-6

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways

Nilambra Dogra, Ashok Kumar & Tapas Mukhopadhyay

Scientific Reports volume 8, Article number: 11926 (2018) Cite this article

Abstract

Drugs that are already clinically approved or experimentally tested for conditions other than cancer, but are found to possess previously unrecognized cytotoxicity towards malignant cells, may serve as fitting anti-cancer candidates. Methyl N-(6-phenylsulfanyl-1H benzimidazol-2-yl) carbamate [Fenbendazole, FZ], a benzimidazole compound, is a safe and inexpensive anthelmintic drug possessing an efficient anti-proliferative activity. In our earlier work, we reported a potent growth-inhibitory activity of FZ caused partially by impairment of proteasomal function. Here, we show that FZ demonstrates moderate affinity for mammalian tubulin and exerts cytotoxicity to human cancer cells at micromolar concentrations. Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) – a key glycolytic enzyme that most cancer cells thrive on. It blocked the growth of human xenografts in nu/nu mice model when mice were fed with the drug orally. The results, in conjunction with our earlier data, suggest that FZ is a new microtubule interfering agent that displays anti-neoplastic activity and may be evaluated as a potential therapeutic agent because of its effect on multiple cellular pathways leading to effective elimination of cancer cells.

As a consequence of this, there’s a bunch of men with protate cancer that are using it as something of a last hope. Some with the help of their M.D. and some on their own.

I also ran into discussion of it for killing off warts. It halted the human papilloma virus. So having a scrap of it left over, and having a dozen or so tiny warts about the size of the head of a pin on the tops of my feet and backs of my knees (where the skin is thinest and scratching more likely), I smeared it on for about 3 days (then I ran out). Just a thin film one or 2 times a day. That was a couple of weeks ago.

Inspection of my feet and the backs of the knees (hello mirror…) showed the tiny warts are gone. They had been there, slowly increasing in number, for about 30 years. Now it’s just skin.

So yeah, on my next run to the Pet Store getting another tube of fenbendazole is on the cards. It’s always nice to have a dewormer on hand, but one that stops warts, kills viruses, and in a pinch whacks on cancer cells? Now that’s special!

Here’s an interesting page listing all sorts of other drugs that can have uses off-lable as an anti-cancer agent. It’s a fascinating list.

https://www.canceractive.com/article/an-offlabel%20drugs%20protocol%20for%20cancer

Here’s a sample out of the middle of the list. Why? Because some of these were a big surprise to me.

* Doxycycline – breast cancer, prostate cancer; converts cancer stem cells to mere mortals in conjunction with berberine or IVC; however it has its problems. See here

* Melatonin – Some oncologists refer to it as ‘The sleeping drug’. But it reduces natural oestrogen, is anti-inflammatory and has at least 5 different ways of attacking cancer cells. It is almost universally effective. See Here

* Naltrexone – as Low Dose Naltrexone (LDN) and used with vitamin D and alpha lipoic acid, has almost universal ability to boost the immune system and provide some pain relief. Increasingly used with cannabis at night and CBD by day.

Then there are at least another 10 drugs with a number of research studies on specific cancers, for example,

* Accutane – GBM, neuroblastoma, breast cancer (with metformin) and can correct cancer stem cells. (But accutane has strong side-effects)

* Celebrex – prostate, lung, breast, colorectal, brain cancer

* Cimetidine – colorectal cancer, gastric cancer, melanoma, kidney cancer; Independent review on Cimetidine and cancer HERE

* Dipyridamole – melanoma, colorectal, breast, TNBC (works well with the anti-histamine cimetidine)

* Fenbendazole – GBM, NSCLC, lymphoma, metastatic Colorectal Cancer, prostate cancer (also blocks uptake of sugar).

* Itraconozole – pancreatic, NHL, endometrial, NSCLC, prostate, breast cancer and TNBC

* Ivermectin – Lymphoma, leukemia, and solid tumours such as ovarian, TNBC and breast cancer.

In Conclusion

So it looks like there are lots of potential drugs, many available OTC, that can be used for slowing, stopping, or curing virus infections and cancers (many caused by viruses).

In particular, Fenbendazol did a dandy job on some very small warts. I need a new tube so I can try it on a wart on the sole of my foot where the skin is a whole lot thicker and that lack of absorption issue may show up. Sure, I could just go get it frozen… but where’s the fun in that?

I don’t know that I’ll ever need to explore the potential use against cancer. Let’s hope not. OTOH, nice to know about “for that day”.

There are related compounds in the same family that have shown promise on other cancers. In particular brain cancer. So this looks like a very fruitful area of drug development.

Subscribe to feed

About E.M.Smith

A technical managerial sort interested in things from Stonehenge to computer science. My present "hot buttons' are the mythology of Climate Change and ancient metrology; but things change...
This entry was posted in Biology Biochem, Emergency Preparation and Risks, Science Bits and tagged , , , . Bookmark the permalink.

51 Responses to Fenbendazole – A Suprise From A Generic Dewormer

  1. Bill In Oz says:

    Thanks for all that EM. Looks like Fenbendazole is a handy drug to have about in the medicine chest, I imagine it is available from pet shops here as well..
    You mentioned melatonin…The Thai medical News web site had a big post about melatonin as a cure for corona lots of links in it.

    The interesting thing is that children and teenagers have a high natural production of melatonin and hardly any kids get sick from Corona virus. The elderly n the other hand are very susceptible to Corona virus and have a severely reduced level of melatonin.
    Yes association not causation. But again it is an OTC drug, a natural hormone and very very cheap.

    I take it as part of my own anti ageing program

  2. H.R. says:

    Hmm… I’ve been taking melatonin for 6-7 years. My old job had my mind racing 24/7 and it really helps one to let go of all those stray nagging thoughts that makes getting to sleep very difficult.

    It’s listed above as a treatment, but it looks like it might be useful as a preventative for some cancers. Hard to say.
    .
    .
    It does have a side effect; really weird dreams. Nothing scary or anything like that. They are just totally out in left field compared to the usual dreams people have that are usually related to events of the day that your brain is working on. I think the best descriptor is non sequitur dreams.

  3. H.R. says:

    Your post appeared when the page refreshed for my post, Bill In Oz. That’s some interesting additional info. Thanks!

  4. Bill In Oz says:

    No dreams HR bother me.
    I do have a very sleepy head when I wake though..Need a good hot shower to get going in the morning after Mlotonin.. Usually 4 by 10 mcgs a night is my dose.

  5. A C Osborn says:

    At last a proper study of HQC + Azithromycin + Zinc Sulphate.

    Click to access 2020.05.02.20080036v1.full.pdf

    Added to the database, I need to provide another printout, but the number of links are a problem.

  6. cdquarles says:

    @ACO,
    Nice study, decent design and decent numbers such that it is suggestive. A problem with it, though, is that it uses p-values. Therefore, it may not generalize well.

  7. A C Osborn says:

    cd, I was just looking at the overall numbers, I am not interested in Stats unless the numbers are not easily understood. Table 4 says it all for me.

    It is hard to find studies that actually use Zinc in their treatment even though that is the recommendation.

  8. spetzer86 says:

    If you really wanted to boost absorption, look at dissolving the fenbendazole in DMSO. This will likely significantly increase topical absorption, which will probably drastically increase the rate of side effects. A variation would be dissolving the fendbandazole in DMSO, filtering it, and using that as a direct injection into the prostate. Careful drug concentration and dosage selection might give you finely dispersed drug particles concentrated in the prostate.

  9. p.g.sharrow says:

    @ACO; most Doctors are taught that they should ignore Vitamins and Trace minerals as those are generally provided adequately in the American Diet. At least that is their point of view that supplements are a waste of money and any concern a waste of their time. Big Pharma, that provides much of their research and training, would rather push HIGH value added products. Any cheap readily available solutions are denigrated as “Un-proven” .
    As a livestock Farmer I had to learn nutrition for rapidly growing animals. How to keep them healthy on the cheap, with readily available, generally local feed stocks. Feed stocks will carry the same Micro-nutrients signature as the soils they are grown in and rapidly growing animals require larger amounts of micro-nutriants for optimum health. Long lived, slow growing human bodies tend to mask any short term shortages that might be replenished due to human varied diet. Sub-optimum health is not generally an American Doctors per-view as they are generally involved in solving more critical problems with Big Pharma medications. Problems we know that have a root cause, long term Micro-nutriant shortages. Shortages made worse by our modern industrialized food system.
    Another reason the medical profession poo-poo’s supplements is their over use by untrained people can cause serious problems as well. “A little bit of education is a dangerous thing.” so if you learn enough to use supplements, learn a bit more to know if you are using too much. Some metal micro-nutrients like Selenium give much the same symptoms in excess as they do in shortage.
    Live Long, and Prosper! …pg

  10. cdquarles says:

    That nailed it, p.g.; though, unless it has changed, the medicos are taught differential diagnosis. You first look at what’s common; and vitamin/mineral deficiency or excess is not thought to be common in the USA. So, it is more accurate to say downplayed than ignored; since most of the time vitamin/mineral deficiency or excess isn’t there or can’t be shown to be relevant.

  11. A C Osborn says:

    PG, my son has fibromyalgia, amongst other things.
    We did not have regular checkups here in the UK so we have no idea what the state of our immune system is like.
    So it came as a shock that after months of seeing various doctors and specialists, tests and scans an old “private” doctor looked at his file and immediately said his Vatamin B12 was at a critical level.
    He had Vitmain B injections and improved a lot.
    It appears that the medical profession have forgotten about good old fashioned “basic” medicine.
    They spent a fortune on CT & MRI Scans and Xrays, which ruled out lots of things but missed the simple Vitamin defficiency.
    It is like Female HRT treatment here, it is one size fits all because they don’t test the individuals normal levels prior to the onset of the menopause, unlike Australia that do.

    Sometimes I despair and it gets worse when treatments are ignored or suppressed.

  12. cdquarles says:

    Another thought about this illness occurs to me. What if the big problem here is that we had at least two significant viral illnesses going on concurrently. And yes, that link I posted in WOOD is suggestive of it.

  13. H.R. says:

    p.g.: “[…] so if you learn enough to use supplements, learn a bit more to know if you are using too much.”

    That’s what put me off of taking any supplement until recently. Someone on TV, or an acquaintance, or an article would go on and on about a vitamin or supplement that was THE miracle cure for whatever and the person touting it would invariably pooh-pooh everything else. They believed in one magic bullet, and oh by the way, you needed to take extremely high doses of the miracle vitamin. If a little is good, a lot is better and an excessive amount must be best. Ugh!

    Anyhow, what got me to start changing my mind was a problem with the sciatic nerves in my hips. Mom told me to take manganese. No thanks. Then she told me that my uncle took it for sciatic nerve flareups. I knew my uncle was very much a skeptical, science-grounded guy, so I figured if he endorsed it for sciatica, then it probably worked as advertised. It did. “It’s a miracle, I tell ya!”

    I’m just starting on my second bottle in about 15 years. You only need one pill or rarely a second pill the next day for a bad flareup. And since I started taking a multi-vitamin that has manganese in it for the other trace elements, I have had to take a manganese pill maybe once or twice a year, usually after the long drive to or from Florida where my butt is bent for hours and I’ve forgotten to take my wallet out of my hip pocket.

    So we’ve had some good discussions and info here on E.M.’s blog about vitamins, and one thing that I appreciate is that the issue of too much is always discussed. “The poison is in the dose” gets brought up here from time to time, and it is important for things that are good for you in the right amount. They can be toxic if you get all enthusiastic and carried away.

    Also, the balance between other vitamins and minerals is usually covered here. For example, I’m now of the mind that the wonders of vitamin C aren’t so much in the C itself, but it seems so important to have C for other vitamins and processes to work properly. I think of C in terms as somewhat like a catalyst than C just doing something directly to some bug or other.

    Anyhow, it can’t be stressed enough; too much can be worse than running a bit short.

  14. Simon Derricutt says:

    H.R. – how much Manganese? Reason is that I’m currently crocked with sciatica and the normal fix of accupressure in the right place hasn’t worked to get rid of it. I’ll explain the accupressure fix if asked – said to work 90% of the time, and takes around 10 seconds. Sorry for OT, but I can’t even sit at the desk for any work but need to be on the floor. Nuisance. Already taking a multi vitamin and mineral pill that should have most stuff in it, but maybe not quite adequate, and I don’t remember it daily anyway.

    I went back to read the bunny saga, and again I marvel at the depth of digging EM achieved. Mostly on this blog I try to add only when I think it will be useful, so I end up receiving far more than I get. Stuff here is often in advance of the news. For the WuFlu, having that information could save a life. So thanks for the work, folks!

  15. p.g.sharrow says:

    @Simon; as each of us contributes a little the whole is large, whether information or entertainment 8-) we all walk away with riches…pg

  16. H.R. says:

    Be sure to get chelated manganese. I forget why because it was years ago when I read up on it. Better uptake into the body, I suppose.

    I take a 10 mg tablet now for a flareup because manganese is in my multivitamin.

    That first jar I had was 20 mg tablets and the article I read warned that if you take 20 mg, then take it every other day. Maybe the 20 mg was the reason I rarely had to take a second pill. I also wasn’t taking a multivitamin then.

    So it looks to be that more than 10 mg/day on average (20mg every other day, same thing) is where problems can start.

    If you only use it for sciatic flareups, you’ll not be taking much of it anyhow.

    I feel for ya, brother. Thank goodness the shooting pain only hits when you move… or sit still ;o)

  17. YMMV says:

    “page listing all sorts of other drugs that can have uses off-lable as an anti-cancer agent. It’s a fascinating list”

    Indeed. Is there any drug which only does one thing? and does it well :-)
    They all have side effects. Usually those are bad, but wow.

    Melatonin – gives better sleep. Side effect – cures cancer.
    hydroxychloroquine – prevents malaria. Side effect – prevents Covid-19.
    and so on. Note, that’s a sarc, not medical advice, in case Dr. Faux is listening.

  18. E.M.Smith says:

    @Bill In Oz:

    As prepper stock, I like to have a collection of basic / field expedient drugs along with several field medical guides, the pharmacopia of (about) 1895 that lists many plants and a field Guide to plants of north America. I was very surprised to discover that anti viral and anti cancer drugs were OTC, if experimental and off label. All owed in part to bunnies….

    While I strongly prefer the attentions of a professional M.D., that isn’t always available in various AwShit events. That’s what Prepping is all about. You hope to never need it, but better than nothing. Just like an M.D. ought to know how to cook over a camp fire, the cook ought to know how to treat a burn. Even if both usually stick to their best skills.

    Fenbendazole is in all sorts of dewormers for many species. Big tubes for horses (what I got for a flock of bunnies) fairly cheaply. The prostate DIY guys talk a lot about dog version vs fish… it’s pretty much everywhere from pet stores to farm supply.

    Melatonin was one that caught me by surprise. Never expected it to do more than make you sleepy. Definitely a Dig Here! needed.

    @P.G.:

    I think that growing up raising animals was my foundation event. We did our own cattle injections, worming, minor surgey, etc. You are expected to have a basic medical skill level. Then feed was very different for each species. You must know their different needs. Not just enough to avoid sickness, but to get optimal health & growth or no profit for you… Even basic anatomy during slaughter and preparation (not to mention epidemiology, animal psychology, etc.) Farmers talk more about trace nutrients than M.D. by a lot in my experience. Every feed bag lists them.

    @H.R.:

    Yeah, that over enthusiasm bugs me too. There’s a minimum effective, an ideal, and a max effective, then you get into toxic doses. Even water and salt have that pattern. Drug without that understanding is beyond stupid headed toward damaging.

    Manganese eh? I’ve become increasingly pleased with the cheap-assed Walmart house brand “Men’s 50+ multivitamin” house brand Equate. Every time some new trace mineral gets the spotlight, there it us. Manganese 4.2 mg 200% “daily value” (that isn’t RDA as regulators screw around with definitions)

    @Simon:

    There’s your dose number.

    There’s several good exercises for hip joints. One is on all fours, arch butt and shoulders up, stomach down. Another is lay flat on the floor and twist the spine by putting right leg over the left as close to the floor as possible. Then the same left over right. Combine with some hip tilts at the full twist point can help.

  19. Nancy & John Hultquist says:

    H.R. : “. . . and I’ve forgotten to take my wallet out of my hip pocket.”

    I’ve not carried a wallet in a hip pocket for many (35?) years.
    That was the left hip. About 10 years ago I did a spin of ice and used my right leg in a way not intended. The piriformis muscle can compresses the sciatic nerve. In some folks the nerve goes through the muscle. Me? Maybe. Anyway, it took 6 months to get better. I’m more careful now.

  20. Simon Derricutt says:

    Nancy and John – seems it’s the piriformis muscle compressing the sciatic nerve is the one that can mostly be fixed by accupressure. The explanation I was given is that the muscle cramp caused a buildup of lactic acid because of reduced blood-flow, and that reduced the blood-flow, so vicious circle. The cramped muscle compresses the nerve and causes the pain. Fix by applying as much pressure to the piriformis muscle as you can using your thumb, keep the pressure applied for 10 seconds, then suddenly release it. The pressure squeezes old blood out of the muscle, and releasing it allows new blood in thus allowing the lactic acid to pass into the blood and removing the cramp. Finding the precise pressure point is a bit difficult, and it’s in the “dimple” of your bum. If the first attempt doesn’t get rid of the pain, try a few more times. I’ve had success for the last 3 times after the initial professional cure, so it can be done. Worth trying instead of being in pain for 6 months….

  21. jim2 says:

    I’m sick and tired of hearing Dimowit politicians squawk about basing policy on science. In the Covid-19 case, “science” means “Fauchi.” Now, I consider him a scientist and probably a good one. After all, everyone has made mistakes concerning this virus. (I exempt his stance on HCQ, that’s a crime.) However, Fauchi is rendering an expert opinion on what policy should be. That isn’t science, it’s still just an opinion. The problem is the Dimowits cherry pick Fauchi’s opinion. There are other epidemiologists with opinions that differ from Fauchi’s.

    But worse than that there are other equally qualified scientists and experts in other fields and their opinion needs to be solicited, heard, and taken into account. We need experts on the medical and psychological effects of unemployment and isolation. How many people will get sick in some way or another or even die? Alcohol and opioids?

    I find my paycheck satisfying, but a job can be more than that. The work itself makes one feel productive and useful and it usually involves social interaction that some people enjoy.

    But beyond all that, there is the problem of research that is never reproduced. Many times when that attempt is made, reproduction fails to obtain the same result. My feeling is this is a much bigger problem than people realize. We really don’t know because people would rather do original work than try to reproduce that of others. It’s also expensive and donors would rather fund original research.

    Anyway, the point is that this “policy by science” is nothing more than a veneer. Politicians can cherry pick the science, or opinions of scientists, to achieve the political result desired.

  22. Nancy & John Hultquist says:

    @ Simon 12:26

    Thanks. Next time I’ll try the pressure trick.

    When my spin on the ice occurred we had just a dial-up connection to the internet, and I was not able to do much. We got DSL in fall of 2008. “Musings from the Chiefio”, with comments, and blogs by others have made the last 12 years educational in many ways – not possible prior to then.
    Thanks to E.M. and others.

  23. A C Osborn says:

    EM, this report in the Guardian should make interesting reading for President Trump.
    It makes it look like COVID-10 is a gene taylored ethnic based weapon.
    And guess which Ethnic group is at the bottom of list.

    https://www.theguardian.com/world/2020/may/01/british-bame-covid-19-death-rate-more-than-twice-that-of-whites

  24. A C Osborn says:

    I suppose I should have included the list.
    Registered hospital deaths from Covid-19 per 100,000 in England
    Other ethnic group 80
    Black Caribbean background 78
    Other black background 53
    Indian background 35
    White Irish background 31
    Other Asian background 30
    Pakistani background 30
    Black African background 30
    White British background 27
    Bangladeshi background 23
    Other white background 22
    Chinese background 15
    Mixed ethnicity 10

  25. rhoda klapp says:

    80 other ethnic group. What other ethnic group?

  26. A C Osborn says:

    This is an interesting study of the aveage amount of Vitamin D plotted against Cases per Million showing the dramatic affect of more Vitamin in reducing cases.
    It is just a pity that Professor Keith Neal who did the study appears to be clueless with numbers.
    For some examples.
    His graph shows the UK having 1000/M, when we actually have 3489/M
    He shows Sweden at around 900 when they have 2894/M.
    He shows Spain at around 3100 when they have 5868/M.

    In other words his data is very old, or he is incompetent.

    https://www.dailymail.co.uk/news/article-8325855/Has-warm-spring-suppressed-UKs-outbreak-Coronavirus-fell-sunniest-April-record.html

  27. E.M.Smith says:

    https://www.foxnews.com/science/covid-cure-california-biopharmaceutical-coronavirus-antibody-breakthrough

    EXCLUSIVE — A California-based biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person’s system within four days, Fox News has exclusively learned.

    Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide “100% inhibition” of COVID-19, adding that a treatment could be available months before a vaccine hits the market.

    “We want to emphasize there is a cure. There is a solution that works 100 percent,” Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. “If we have the neutralizing antibody in your body, you don’t need the social distancing. You can open up a society without fear.”

  28. YMMV says:

    @A C Osborn, “this report in the Guardian”

    Looking for the original on that I found various news reports, all stressing their particular victimhood.
    I finally found the original. And I must say, ONS (Office for National Statistics) in the UK is very impressive.

    https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/articles/coronavirusrelateddeathsbyethnicgroupenglandandwales/2march2020to10april2020
    “Coronavirus (COVID-19) related deaths by ethnic group, England and Wales: 2 March 2020 to 10 April 2020”
    and some downloadable data here (.xlsx):
    https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/datasets/oddsratiosforriskofcoronavirusrelateddeathsbyethnicgroupenglandandwales
    “Odds ratios for the risk of dying from the coronavirus (COVID-19) by ethnicity in England and Wales”

    “These results show that the difference between ethnic groups in COVID-19 mortality is partly a result of socio-economic disadvantage and other circumstances, but a remaining part of the difference has not yet been explained.”

    We already know that some ethnic groups are disadvantaged by Vit-D levels et al, so this is not that surprising.

    Saying “It makes it look like COVID-10 is a gene taylored ethnic based weapon” is going a step too far, giving ChiCom more credit than they are due, but a good case has been made that the gene sequence history shows it was made in a lab.

  29. E.M.Smith says:

    @AC Osborn:

    Much more likely differences in vit-D level than an engineered bioweapon biased by race. Thousands of times more likely.

    Chinese in the UK will be very light skinned, nearly white. Plus they are likely getting a good vit-D level either through supplements or diet (more fish and animal products)

    Look at the data on vit-D deficiency by race, Blacks much more often have low levels and even rickets.

  30. YMMV says:

    HCQ news:
    https://www.jpost.com/health-science/italian-scientist-says-she-discovered-main-mechanism-behind-covid-19-626737

    This news article reports an idea and then says it is controversial and reports criticism, which is standard practice. Who knows how solid this is.

    The virus “needs porphyrins for its survival – and probably for its replication – so it attacks hemoglobin”.

    “In men the normal value of hemoglobin (Hb) is higher than in women. This would explain the higher incidence of COVID-19 pneumonia in men compared to women, and the lower incidence and better prognosis in children and pregnant women, where Hb values are lower due to an increased need of iron, which makes less available this ‘nutrition’ for the virus.”

    HCQ “binds to the ferriprotoporphyrin of the ecgonine methyl ester (EME), blocking the key enzyme of malaria. “So, I thought this same mechanism could be used against SARS-CoV-2… Indeed, a study by a Chinese university shows that SARS-CoV-2 binds to the beta chain of hemoglobin, inhibiting EME metabolism.”

    “The Italian Medicines Agency (AIFA), the national authority responsible for drug regulation in Italy, has an approved trial of hydroxychloroquine on 2,500 patients, which will start in early July and focus on the use of hydroxychloroquine in prophylaxis, Chiusolo said. The study, for which preliminary data would be ready within 16 weeks, will look at whether the preventive intake of the drug decreases the probability of contracting COVID-19 when one comes directly into contact with a positive patient.”

    “Furthermore, Chiusolo told the Post, the Italian Society of Rheumatology interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65,000 chronic lupus and rheumatoid arthritis patients who systematically take hydroxychloroquine, only 20 patients tested positive for the virus.”

  31. YMMV says:

    Two hopeful antibody treatments:

    More on the report mentioned above
    https://investors.sorrentotherapeutics.com/news-releases/news-release-details/sti-1499-potent-anti-sars-cov-2-antibody-demonstrates-ability
    “STI-1499, A Potent Anti-SARS-CoV-2 Antibody, Demonstrates Ability To Completely Inhibit In Vitro Virus Infection In Preclinical Studies”

    Another one in the news. This one uses two antibodies at once.
    https://science.sciencemag.org/content/early/2020/05/12/science.abc2241
    “A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2”

    And more reasons why we might not take up a vaccine. If they ever get one.
    https://www.rt.com/op-ed/488831-coronavirus-vaccine-disaster-warnings-swineflu/

  32. A C Osborn says:

    So currently Italy is at 3702/Million, which would give 241 for 65,000 people.
    Less than 1/10th of normal for those on HCQ..
    Every country should have done the same thing.
    But they don’t want to know do they, too many invested interests elsewhere.

  33. Power Grab says:

    As much as I am glad to keep hearing people say that vitamin D helps us ward off Covid and suchlike, here is a new article that describes how getting vitamin D from exposure to sunlight is different (and better) from getting it through taking supplements:

    https://www.westonaprice.org/health-topics/sunlight-and-vitamin-d-theyre-not-the-same-thing/

    I sense some “digging” in my future….

  34. A C Osborn says:

    Another article that discusses treating the Immune response to COVID-19 instead of just COVID-19 itself.
    The doctor also says that you have to treat each patient individually once they are critically ill due to each patient’s immune system responding differently to both COVID-19 and the drugs.
    But the interesting part of the article is the criticism of CDC for not holding Clinical Outreach and Communication Activity much more often to disemminate best practices from the front line doctors.
    Just why aren’t CDC doing the job they were designed and are being paid for?

  35. H.R. says:

    A C Osborn: “Just why aren’t CDC doing the job they were designed and are being paid for?”

    Because TPTB at CDC are invested in getting a vaccine because they have invested their personal funds in vaccine makers.

    The CDC is a huge bureaucracy and that right there is a problem. We’ve discussed how bureaucracies fail due to their sheer unwieldy size.

    The CDC should consist of a half-dozen plus/minus doctors and enough clerical staff to record incoming data to disseminate that information to doctors in the field. Let the doctors on the ground do what they are trained to do and give them the information they need to figure out what they need to do for their specific patients. That’s why we have a variety of ways to treat patients now. It wasn’t due to the lightning fast response and brilliance of the CDC.
    .
    .
    .
    Random thought… back when every government agency, including the National Weather Service, was getting ammo, was any ammo ordered for the CDC? You would think not, but it wouldn’t surprise me if they did get some ammo.

  36. YMMV says:

    More on vaccines. This article is about getting vaccine research away from the Fauci slow-walk.
    https://www.americanthinker.com/blog/2020/05/operation_warp_speed_eliminates_faucis_power_to_delay_vaccines.html

    But this is the surprise part. Some vaccines cause Vaccine Enhanced Disease (VED).
    A group of scientists “figured out that the usual cause was the formaldehyde commonly used to prepare some kinds of vaccines. Apparently, formaldehyde causes carbonyl groups to get attached to the Th2 antibodies that are part of the body’s immune system against respiratory diseases, and those carbonyl groups cause the cytokine storms.”

  37. YMMV says:

    Power Grab: “here is a new article that describes how getting vitamin D from exposure to sunlight is different (and better) from getting it through taking supplements”

    That is a good article. Worth reading. It aligns with what others are saying. One thing it does not go into is the difference between UVA and UVB. UVB is good for you. UVA bad, but sunscreen blocks UVB. Or did, maybe that has changed.

    Here is a good paper, predating Covid-19.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/
    “Sunlight and Vitamin D: A global perspective for health”

    This article also predates Covid-19.
    https://healthimpactnews.com/2017/study-vitamin-d-is-more-effective-than-flu-vaccine/
    Vit-D supplements are especially effective if you have a Vit-D deficiency.

    But Vit-D levels are also an indicator of metabolic and cardiovascular health, insulin resistance, and supplements cannot fix those problems. To fix that, you need to fix your diet.

    Ivor Cummins discusses that aspect on his YouTube channel. In this episode he appears on another doctor’s podcast, so this episode is almost a review. It’s long but worthwhile.
    https://thefatemperor.com/ep76-if-you-think-you-understand-the-current-viral-issue-you-dont/
    In particular, watch the minutes starting at the 1 hour mark. Older people do not have to have that covid target on their back.

  38. jim2 says:

    Good piece today from Sharyl Attkisson on hydroxychloroquine cover-up:

    http://fullmeasure.news/news/cover-story/hydroxychloroquine

  39. H.R. says:

    YMMV: “But this is the surprise part. Some vaccines cause Vaccine Enhanced Disease (VED).”

    That does it for me. No flu vaccine is hitting my arteries. I’ll stick with Vitamin D. Thanks for that info, YMMV.

    BTW, it was nice and sunny here today, so I got my dose of au natural vitamin D. I still am taking supplements to cover any gaps in sun exposure. April showers are running late and we’ve had spotty sunny days here with more precipitation in the forecast.

    May showers bring June flowers just doesn’t have the same ring to it, eh?

  40. YMMV says:

    https://www.nature.com/articles/s42256-020-0180-7
    “An interpretable mortality prediction model for COVID-19 patients”

    To support decision making and logistical planning in healthcare systems, this study leverages a database of blood samples from 485 infected patients in the region of Wuhan, China, to identify crucial predictive biomarkers of disease mortality. For this purpose, machine learning tools selected three biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). In particular, relatively high levels of LDH alone seem to play a crucial role in distinguishing the vast majority of cases that require immediate medical attention. This finding is consistent with current medical knowledge that high LDH levels are associated with tissue breakdown occurring in various diseases, including pulmonary disorders such as pneumonia.

    These indicators are for when you have covid and are in the hospital.
    I’m still waiting for the indicators to predict how bad it will be if and when you get it — before you get it. That is, reassurance it’s no big deal versus run and hide.

  41. A C Osborn says:

    llanfar says: 18 May 2020 at 3:17 am
    Won’t see that on the BBC or in the US MSM.
    Remdesivir and Vaccines are all they will promote.

    I will add it to my database, thanks

  42. cdquarles says:

    @H. R.
    Do note that the same processes that happen with vaccine enhanced/antibody enhanced disease happen with the ‘natural’ infection(s), too.

  43. cdquarles says:

    Think adjuvants, where these were added specifically to enhance immune response.

  44. E.M.Smith says:

    @Ilanfar:

    Interesting… and a dig gives:

    https://www.ncbi.nlm.nih.gov/pubmed/26459887

    Antiviral activity of doxycycline against vesicular stomatitis virus in vitro.
    Wu ZC1, Wang X2, Wei JC1, Li BB1, Shao DH1, Li YM1, Liu K1, Shi YY1, Zhou B3, Qiu YF1, Ma ZY4.
    Author information
    Abstract
    Doxycycline (Dox) is a tetracycline derivative with broad-spectrum antimicrobial activities that is used as an effector substance in inducible gene-expression systems. We investigated the antiviral activity of Dox against vesicular stomatitis virus (VSV) infection in cultured H1299 cells. Dox at concentrations of 1.0-2.0 μg ml(-1) significantly inhibited VSV replication and the VSV-induced cytopathic effect in dose-dependent manners, suggesting that Dox may have broader activity in inhibiting viral replication, in addition to its well-defined bacteriostatic activity. Dox exerted its antiviral effect at the early-mid stage of VSV infection, suggesting that it did not interfere with VSV infectivity, adsorption, or entry into target cells. These results indicate that Dox can inhibit VSV infection and may therefore have potential applications for the treatment of viral infections.

    .

    https://www.ncbi.nlm.nih.gov/pubmed/24142271

    Inhibitory effect of doxycycline against dengue virus replication in vitro.
    Rothan HA1, Mohamed Z, Paydar M, Rahman NA, Yusof R.
    Author information
    Abstract
    Doxycycline is an antibiotic derived from tetracycline that possesses antimicrobial and anti-inflammatory activities. Antiviral activity of doxycycline against dengue virus has been reported previously; however, its anti-dengue properties need further investigation. This study was conducted to determine the potential activity of doxycycline against dengue virus replication in vitro. Doxycycline inhibited the dengue virus serine protease (DENV2 NS2B-NS3pro) with an IC50 value of 52.3 ± 6.2 μM at 37 °C (normal human temperature) and 26.7 ± 5.3 μM at 40 °C (high fever temperature). The antiviral activity of doxycycline was first tested at different concentrations against DENV2 using a plaque-formation assay. The virus titter decreased significantly after applying doxycycline at levels lower than its 50 % cytotoxic concentration (CC50, 100 μM), showing concentration-dependent inhibition with a 50 % effective concentration (EC50) of approximately 50 μM. Doxycycline significantly inhibited viral entry and post-infection replication of the four dengue serotypes, with serotype-specific inhibition (high activity against DENV2 and DENV4 compared to DENV1 and DENV3). Collectively, these findings underline the need for further experimental and clinical studies on doxycycline, utilizing its anti-dengue and anti-inflammatory activities to attenuate the clinical symptoms of dengue virus infection.

    Golly.

  45. chiff says:

    I haven’t followed this for a couple of years. No opinion but maybe of interest here
    https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective

  46. Sabretoothed says:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/ Ivermectin also works on everything too even Corona. I think there is massive denialism that worms are causing a lot of “diseases” that the west says. If corona can come to USA then worms can come too. The 3rd world is full of worms and amazingly there are none in USA according to the Mainstream media ;)

  47. Sabretoothed says:

  48. Power Grab says:

    @ Sabretoothed:

    Thanks for sharing that. I had heard through Dr. Tom Cowan that Dr. Andy Kaufman was a good source for the explanation that exosomes are what we otherwise call “viruses”. That video does include the electronmicroscope images that show them to appear the same. He also delineates many of the same causes as I listed in my “perfect storm” list.

Anything to say?

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.