Truth? Or Consequences? Or And?

When I first saw this story I thought “Looks like Click Bait or maybe Paranoid Fantasy”.

Digging into it a bit, it now looks like the guy’s basic science is right, and his concerns have some merit. There’s still way too many “could” and “might” and maybe type qualifiers in the article, and it is in an “also ran” type “journal”. Yet his claims about other diseases (that was part of my dismissal) have in fact checked out.

In The News

“Popular Press” version:

https://www.thegatewaypundit.com/2021/04/report-pfizer-moderna-covid-vaccines-trigger-alzheimers-als-neurological-degenerative-diseases/

Report: Pfizer and Moderna COVID “Vaccines” Could Trigger Alzheimer’s, ALS, and Other Neurological Degenerative Diseases
By Jim Hoft
Published April 25, 2021 at 1:53pm

Everyone from Joe Biden to Red Pope Francis is pushing for 100% acceptance of the mRNA vaccine for COVID. The vaccine is unproven and untested. No one knows if the vaccine is more dangerous than the disease.

Over 50 percent of new COVID cases involve people who have already been vaccinated, [as reported on The Gateway Pundit earlier, according to a Yale epidemiologist]).

Now, a startling new report in *Microbiology and Infectious Disease* finds the mRNA vaccines could trigger Alzheimer’s disease, ALS, and other neurological and cognitive degenerative diseases.

Dr. Classen and his associates found that the vaccine increases the likelihood of these hideous diseases by opening a pathway into human DNA, which is exactly what this gene-therapy drug is intended to do:

The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme.

The “Greek pitchfork” psi letter is intended to mean a variant form of U Uracil named 1-methyl-3′-pseudouridylyl used in the vaccine for God Only Knows why.

It goes on from there into the supposed risk of more zinc inside the cells:

More about that issue with zinc:

This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases.

Since Zinc is essential to several dozen enzyme systems and is increased via drugs like HCQ / Quinine / Quercitin to help prevent viral replication, I’m a bit sceptical of that claim and would like to know if this was found via an in vitro test with massive zinc… but I digress.

Going down the Rabbit Hole:

The Paper

Here’s the PDF of the report:

https://www.hennessysview.com/images/covid19-rna-based-vaccines-and-the-risk-of-prion-disease-1503.pdf All of 3 pages long, full of maybes of various kinds.

COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Classen Immunotherapies, Inc., 3637 Rockdale Road, Manchester,
MD 21102, E-mail: classen@vaccines.net.
J. Bart Classen, MD*
Citation: Classen JB. COVID-19 RNA Based Vaccines and the Risk of Prion Disease. Microbiol Infect Dis. 2021; 5(1): 1-3.
Research Article

ABSTRACT

Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARSCoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) into their pathologic prion conformations. The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.
[…]
Methods

Pfizer’s RNA based vaccine against COVID-19 was evaluated for the potential to convert TDP-43 and or FUS to their prion based disease causing states. The vaccine RNA was analyzed for the presence of sequences that can activate TDP-43 and FUS. The interaction of the transcribed spike protein with its target was analyzed to determine if this action could also activate TDP-43 and FUS.

So basically they loooked at the vaccine RNA looking for sequences similar to those that create protein segments that cause mis-folding of proteins in other Prion diseases. OK… So not a smoking gun, not even a gunshot victim. Just saying “does it look like the outline of a gun?”…

Weak tea. OTOH, you can’t exactly go around injecting an experimental RNA segment into people and creating an experimental spike protein fragment to find out IF in fact it will screw up their brains in a decade or two. Oh. Wait…

Results

Analysis of the Pfizer vaccine against COVID-19 identified two potential risk factors for inducing prion disease is humans. The RNA sequence in the vaccine [3] contains sequences believed to induce TDP-43 and FUS to aggregate in their prion based conformation leading to the development of common neurodegerative diseases. In particular it has been shown that RNA sequences GGUA [4], UG rich sequences [5], UG tandem repeats [6], and G Quadruplex sequences [7], have increased affinity to bind TDP-43 and or FUS and may cause TDP-43 or FUS to take their pathologic configurations in the cytoplasm. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. G Quadruplex sequences are possibly present but sophisticated computer programs are needed to verify these. The spike protein encoded by the vaccine binds angiotensin converting enzyme 2 (ACE2), an enzyme which contains zinc molecules [8]. The binding of spike protein to ACE2 has the potential to release the zinc molecule, an ion that causes TDP-43 to assume its pathologic prion transformation [9].

Now at this point I was thinking “WT?” as I only knew of ONE Prion Disease, the spongiform encephalitis one. Kuro or CJV / vCJV in humans, Mad Cow in cows, Scrapie in sheep, Chronic Wasting Disease in deer. All caused by a misfold of the same PrP protein.

Down below you will find where I went down that Rabbit Hole and found that yes, his claims of Alzheimers, ALS, and others being prion diseases is correct. That’s a real thing.

Skipping down in the paper, he gets a bit paranoid … OTOH, we now know our Dear Leaders are largely Sociopathic Liars For Effect and have a death wish for 90% of the world population, so maybe “just because you are paranoid doesn’t mean they aren’t out to get you” applies…

Over the last two decades there has been a concern among certain scientists that prions could be used as bioweapons. More recently there has been a concern that ubiquitous intracellular molecules could be activated to cause prion disease including Alzheimer’s disease, ALS and other neurodegenerative diseases. This concern originates due to potential for misuse of research data on the mechanisms by which certain RNA binding proteins like TDP-43, FUS and others can be activated to form disease causing prions. The fact that this research, which could be used for bioweapons development, is funded by private organizations including the Bill and Melinda Gates Foundation, and Ellison Medical Foundation [2] without national/international oversight is also a concern.

Jumping on down to the Zink part of the paper:

Zinc binding to the RNA recognition motif of TDP-43 is another mechanism leading to formation of amyloid like aggregations [9]. The viral spike protein, coded by the vaccine RNA sequence, binds ACE2 an enzyme containing zinc molecules [8]. This interaction has the potential to increase intracellular zinc levels leading to prion disease. The initial binding could be between spike proteins on the surface of the cell transfected by the vaccine and ACE2 on the surface of an adjacent cell. The resulting complex may become internalized. Alternatively, the interaction could initially take place in the cytoplasm of a cell that makes ACE2 and has been transfected with the vaccine RNA coding for the spike protein. The interaction is quite concerning given the belief that the virus causing COVID-19, SARS-CoV-2, is a bioweapon [10,11] and it is possible that the viral spike protein may have been designed to cause prion disease.

I would like to know more about just how much zinc it takes and in what context. Being essential to so many functions, I have difficulty with the idea that normal levels of zink can be damaging…

Then we have the Why Psi issue:

Another related concern is that the Pfizer vaccine uses a unique RNA nucleoside 1-methyl-3′-pseudouridylyl (Ψ). According to FDA briefing documents, this nucleoside was chosen to reduce activation of the innate immune system [12]. RNA molecules containing this nucleoside will undoubtedly have altered binding [13]. Unfortunately, the effect on TDP-43, FUS and other RNA binding proteins is not published. The use of this nucleoside in a vaccine can potentially enhance the binding affinity of RNA sequences capable of causing TDP-43 and FUS to assume toxic configurations.

Skipping over some more, he makes an interesting citation that bears investigation, and then returns a to a bit more paranoid context (which I will ommitt this time):

Finally, others working in the field have published additional support that COVID-19 vaccines could potentially induce prion disease. Authors [18] found prion related sequences in the COVID-19 spike protein which were not found in related coronaviruses. Others [19] have reported a case of prion disease, Creutzfeldt-Jakob disease, initially occurring in a man with COVID-19.

So looks like Chinese Wuhan Covid itself might cause the issues too. Sort of a damned if you do, damned if you don’t. I think I’m sticking with Ivermectin…

Do realize that there is genetic variation in the related prion-potential protein formation and it is highly likely some few folks will be extraordinarily predisposed while others will be extraordinarily resistant. So YMMV…

Correspondence:
J. Bart Classen, MD, Classen Immunotherapies, Inc., 3637
Rockdale Road, Manchester, MD 21102, Tel: 410-377-8526.
Received: 27 December 2020; Accepted: 18 January 2021
Microbiology & Infectious Diseases
ISSN 2639-9458
Keywords
COVID-19, Vaccines, Diabetes, Immunity

OK, other bits

Background on what’s a Prion. Looks correct to me. Also includes references to other Prion diseases that I’d not noticed had been worked out. Progress and all that…

https://en.wikipedia.org/wiki/Prion

In other diseases
Prion-like domains have been found in a variety of other mammalian proteins. Some of these proteins have been implicated in the ontogeny of age-related neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U), Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. They are also implicated in some forms of systemic amyloidosis including AA amyloidosis that develops in humans and animals with inflammatory and infectious diseases such as tuberculosis, Crohn’s disease, rheumatoid arthritis, and HIV AIDS. AA amyloidosis, like prion disease, may be transmissible. This has given rise to the ‘prion paradigm’, where otherwise harmless proteins can be converted to a pathogenic form by a small number of misfolded, nucleating proteins.

Even a proposed treatment for such diseases via modulating the genes that code for the protein in question (assuming one can live with it turned off):

https://www.scientificamerican.com/article/antisense-drugs-for-huntingtons-als-and-prion-diseases-could-meet-the-dire-need-for-brain-treatments/

So looks like we’re starting to have a handle on things like Alzheimers and Parkinson’s. Which makes this a bit more believable:

https://z3news.com/w/covid19-mrna-jab-prion-disease-spike-protein-setting-vaccinated-virus/

Has en embedded video of folks with Parkinson’s like symptoms with onset just after vaccination… IMHO, vaccines kill off the folks with variant genetics just a little too far removed from the study group. ( I knew a person in a wheelchair for life after a Polio vaccination… her twin brother did fine.)

Bitchute Channel, Sixth Sense, 32:26 Minute Video

“One of the symptoms of prion disease is muscle control loss, sudden jerks or twitches, exactly the adverse effect many are experiencing. And, we have heard from Bill Gates, and other ‘experts’ that another pandemic is coming, which will be a virus that will be far more deadly. Based on the study highlighted in this video, it may very well be that the Covid-19 vaccine will make the vaccinated far more susceptible to dying.”

Two COVID vaccinated people suffering from uncontrollable body convulsions:

Temora Yuille
Angelia’s Anguish

Those two names being links in the article. So maybe it’s only a few dozen out of millions… Maybe It’s OK to sacrifice a few dozens, or hundreds, to the Gods Of CDC. Or maybe it ought to be more informed consent with “reparations” to the damaged families via liability, and maybe we need to wonder if there’s a Long Term Slow Onset form too…

I also got confirmation of some of the claims about other diseases too:

https://www.sciencedirect.com/science/article/pii/B9780444639455000180

Handbook of Clinical Neurology
Volume 153, 2018, Pages 337-354

Chapter 18 – Prion-like mechanisms in amyotrophic lateral sclerosis
Author Jacob I.Ayers 1 Neil R.Cashman 2

Abstract

The prion hypothesis – a protein conformation capable of replicating without a nucleic acid genome – was heretical at the time of its discovery. However, the characteristics of the disease-misfolded prion protein and its ability to transmit disease, replicate, and spread are now widely accepted throughout the scientific community. In fact, in the last decade a wealth of evidence has emerged supporting similar properties observed for many of the misfolded proteins implicated in other neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, tauopathies, and as described in this chapter, amyotrophic lateral sclerosis (ALS). Multiple studies have now demonstrated the ability for superoxide dismutase-1, 43-kDa transactive response (TAR) DNA-binding protein, fused-in sarcoma, and most recently, C9orf72-encoded polypeptides to display properties similar to those of prions. The majority of these are cell-free and in vitro assays, while superoxide dismutase-1 remains the only ALS-linked protein to demonstrate several prion-like properties in vivo. In this chapter, we provide an
introduction to ALS and review the recent literature linking several proteins implicated in the familial forms of the disease to properties of the prion protein.

The ALS network is on board with the idea:

https://www.als.net/news/als-a-prion-disease/

The buildup of proteins in the brain and spinal cord is a hallmark of ALS. But how these proteins accumulate within the cells of the central nervous system in people with ALS remains a mystery.

Now, researchers from the University of Cambridge in England report that familial ALS type 1-associated superoxide dismutase 1 (SOD1) can spread from neuron to neuron. And once inside these neurons, these misfolded proteins can trigger the aggregation of the cells’ own copies of the enzyme.

These results suggest that ALS may be similar to prion diseases such as the brain disorder Creutzfeldt-Jakob disease. And at the same time, these findings suggest new therapeutic strategies to reduce the buildup of proteins in people with the disease.

In Theory, this now opens the path to research on treatments. Find a molecule that binds to the misfolded form and prevents the replication. Block the gene making the particular protein and hope you don’t need it. Etc.

It also confirms that injecting things shaped like that target is A Very Bad Idea…

NIH has an article too:

https://pubmed.ncbi.nlm.nih.gov/32958236/

The prion-like nature of amyotrophic lateral sclerosis
L McAlary 1, J J Yerbury 1, N R Cashman 2
Affiliations expand
PMID: 32958236 DOI: 10.1016/bs.pmbts.2020.07.002

Abstract
The misfolding, aggregation, and deposition of specific proteins is the key hallmark of most progressive neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). ALS is characterized by the rapid and progressive degenerations of motor neurons in the spinal cord and motor cortex, resulting in paralysis of those who suffer from it. Pathologically, there are three major aggregating proteins associated with ALS, including TAR DNA-binding protein of 43kDa (TDP-43), superoxide dismutase-1 (SOD1), and fused in sarcoma (FUS). While there are ALS-associated mutations found in each of these proteins, the most prevalent aggregation pathology is that of wild-type TDP-43 (97% of cases), with the remaining split between mutant forms of SOD1 (~2%) and FUS (~1%). Considering the progressive nature of ALS and its association with the aggregation of specific proteins, a growing notion is that the spread of pathology and symptoms can be explained by a prion-like mechanism. Prion diseases are a group of highly infectious neurodegenerative disorders caused by the misfolding, aggregation, and spread of a transmissible conformer of prion protein (PrP). Pathogenic PrP is capable of converting healthy PrP into a toxic form through template-directed misfolding. Application of this finding to other neurodegenerative disorders, and in particular ALS, has revolutionized our understanding of cause and progression of these disorders. In this chapter, we first provide a background on ALS pathology and genetic origin. We then detail and discuss the evidence supporting a prion-like propagation of protein misfolding and aggregation in ALS with a particular focus on SOD1 and TDP-43 as these are the most well-established models in the field.

Similar results for Alzheimer’s

https://www.ucsf.edu/news/2019/05/414326/alzheimers-disease-double-prion-disorder-study-shows

Alzheimer’s Disease is a ‘Double-Prion Disorder,’ Study Shows
Self-Propagating Amyloid and Tau Prions found in Post-Mortem Brain Samples, With Highest Levels in Patients Who Died Young

By Nicholas Weiler

This is the caption for a fascinating photo:

The normal form of Aß has been tagged with a yellow marker in these cells, making healthy cells a uniform pale yellow (left). Contact with prion forms of Aß — for example in extracts from human brain tissue — forces these yellow proteins into the sticky prion form as well, leading to the formation of bright yellow clumps (right). Credit: Prusiner lab / UCSF Institute for Neurodegenerative Diseases.

Then back to the article body:

Two proteins central to the pathology of Alzheimer’s disease act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — according to new UC San Francisco research.

Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of the proteins amyloid beta (Aß) and tau in postmortem brain tissue of 75 Alzheimer’s patients. In a striking finding, higher levels of these prions in human brain samples were strongly associated with early-onset forms of the disease and younger age at death.

Alzheimer’s disease is currently defined based on the presence of toxic protein aggregations in the brain known as amyloid plaques and tau tangles, accompanied by cognitive decline and dementia. But attempts to treat the disease by clearing out these inert proteins have been unsuccessful. The new evidence that active Aß and tau prions could be driving the disease – published May 1, 2019 in Science Translational Medicine — could lead researchers to explore new therapies that focus on prions directly.

“I believe this shows beyond a shadow of a doubt that amyloid beta and tau are both prions, and that Alzheimer’s disease is a double-prion disorder in which these two rogue proteins together destroy the brain,” said Stanley Prusiner, MD, the study’s senior author and director of the UCSF Institute for Neurodegenerative Diseases, part of the UCSF Weill Institute for Neurosciences. “The fact that prion levels also appear linked to patient longevity should change how we think about the way forward for developing treatments for the disease. We need a sea change in Alzheimer’s disease research, and that is what this paper does. This paper might catalyze a major change in AD research.”

In Conclusion

At that point I ended the search for validation / confirmation.

It is clear that the specific claims about known prion diseases are accurate. It is clear that the spike protein and RNA vaccine have regions similar to prion mis-folding locations. There’s anecdotal evidence for some folks (limited in number) having “side effects” similar to the cited prion diseases.

I think that (barely) justifies the concern and saying “maybe, could be, possibly, risk, think about it…”

But is it TRUTH? Will we have Consequences? Is it an “and” or an “or”?

At this point nobody knows. But IMHO it is well worth watching and looking and testing and doing all that long term stuff that was skipped.

Me? I’ve had 3 occasions now of an “early onset sniffles & don’t feel right” that resolved the very next day with ONE application of Ivermectin Drench. (I’d rather get the proper deal from my M.D., but with The W.H.O., C.D.C, and N.I.H. all now Political Officer Driven, my M.D. is getting bad “advice” so I’m on my own now.) 10 ml, or the dose for a 200 lb / 100 kg sheep. For those of us who are not sheep… 1 x week or “one and done” in my case as by day 3 there’s nothing left to treat.

Were these Chinese Wuhan Covid onset? Or The Flu? Or The Common Cold? Or maybe even just allergies? No way to know, other than that allergies “feel different” to me and do not go away the next day (seasonal plants).

But even if just A Cold or The Flu, I’m happy with the result. Very happy. Guinea Pig One reporting ;-) but not going to be guinea pig for the two step experimental RNA “whack a gene” therapy…

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About E.M.Smith

A technical managerial sort interested in things from Stonehenge to computer science. My present "hot buttons' are the mythology of Climate Change and ancient metrology; but things change...
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25 Responses to Truth? Or Consequences? Or And?

  1. E.M.Smith says:

    Hmmm…. Wonder if “First Nations” folks are one of those genetic divergences…

    https://rumble.com/vg17a3-whistleblower-doctor-speaks-out-after-first-nations-patients-experience-ser.html

    has video in it.

    “Troubling neurological side effects”…

  2. E.M.Smith says:

    @Taz:

    Fine with me if YouTube TV is booted from Roku. I’m REALLY tired of the repetitive adverts for YouTube TV asking me to sign up….

  3. E.M.Smith says:

    Stray Thought:

    There’s a theory (that I think is valid given my observation of dog breeds among others) that some behaviour is genetically predisposed. Assume for the moment that is true.

    There’s a theory (that I also suspect has some validity) that this “pandemic” and vaccination pogrom is a deliberate act by the GEBs to “thin the herd”. Assume for the moment that is true.

    There is a bit of evidence that the “vaccines” are more likely to damage First Nations and Blacks compared to whites, but plenty of whites are reporting very bad “side effects” some of long duration. Assume for the moment that in fact the vaccines are damaging people, with more to come over time, and it will reduce or eliminate reproduction from large swaths of humanity.

    Those folks most prone to getting vaccinated are those most willing to accept the media “guidance” driven by the GEBs that vaccination is safe, effective and neccesary.

    Those folks most prone to NOT getting the vaccination are those most willing to be sceptical, to think the media daft and diss them, and to think the GEBs are the Greedy Evil Bastards that they are and out to kill off a lot of humanity (as they have said) and HAPPY to give them the big Middle Finger on experimental vaccination with genetic manipulation crap.

    The peculiar conclusion from that is that the “Chinese Wuhan Covid + Toxic Vaccination” will lead to a dramatic increase in those people who are most prone to being Sceptical, Obstreperous, and NOT following directions… I.E. the GEBs (Greedy Evil Bastards), IF the above postulates are in fact true, are mostly removing from society the Sheeple most prone to following their “guidance” and enriching the survivor population in just those people who hate them the most, think them evil, do not trust them, and would be happy to see them all given “The French Hair Cut”…

    Talk about your lack of foresight…

  4. Quail says:

    There has been an increase in the number of deaths from dementia and Alzheimer’s the last two ‘flu’ cycles.

    Another potential problem with the vaccine/virus:
    I’m not sure I understand all this, but it sucks big time if true. The Chinese may have created the perfect bio-weapon for humans and our closest relatives. No wonder they welded doors and turned off internal travel, while crying, “racist,” to any country that blocked their flights. Bio-warfare is an ancient tactic. The Deagle forecast is looking terrifyingly accurate the more I learn.

    The virus reactivates an ancient retrovirus buried in our genes, HERV-W, Human Endogonous Retrovirus W. This is not unique to Wuhan as other viral infections are suspected to reactivate this or other HERV’s. Some of the symptoms of this retrovirus activation are diabetes, MS, cancer, and rheumatoid arthritis. They are proposing to use blood levels of the retrovirus and a marker for severe disease.

    This retrovirus is normally read by our body like any other DNA and codes a protein called Syncytin-1. It has been part of our genetic code since an ancient ancestor was infected by it, and has become essential for the development of placentas in humans, apes, and old world monkeys. This protein is used by in the female body to enable the placenta to attach to the mother’s uterus and keep her white blood cells from invading and destroying the developing fetus.

    Unfortunately, the spike protein is a very close analog to protein coded by the retrovirus. The vaccine and possibly the virus are training the body to attack that protein as non-self, causing miscarriages and heavy menses. This may possibly be a permanent alteration.

    HERV-W Triggering it has been linked to MS and diabetes, plus other autoimmune problems.
    https://en.wikipedia.org/wiki/Human_Endogenous_Retrovirus-W

    The essential protein, Syncytin-1, is coded by it. It helps the placenta attach to the uterus.
    https://en.wikipedia.org/wiki/Syncytin-1
    https://en.wikipedia.org/wiki/Syncytiotrophoblast
    It also may be involved in attaching sperm to egg allowing fertilization to occur.
    https://link.springer.com/article/10.1007%2Fs10815-014-0224-1

    Here is a paper saying there is very limited similarity between the spike and syncytin-1. Starts on page 8.

    Click to access biology-10-00238.pdf

    HOWEVER, what really matters is how the protein is cut and folded, and what is on the outside for the immune system to recognize. The article above only addresses the sequence of codons. Proteins are often chopped up or added to inside the cell before being transported out into circulation. I tried running BLAST to compare them, but frankly, I do not know enough to do it properly.

    Retrovirus is activated during covid infection.
    https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00134-1/fulltext

    Can be activated even by UV inactivated virus, by the spike protein itself. This is one of the reasons why there is concern that the vaccine is not safe.
    https://www.researchsquare.com/article/rs-301236/v1

    Many reports of heavy menstrual bleeding or irregularities after vaccination and infection.
    https://www.bmj.com/content/373/bmj.n958/rr-2

    Background on worries about fertility and vaccines. Also why Africans have very little interest in vaccines.
    https://www.africanglobe.net/africa/mass-sterilization-kenyan-doctors-find-anti-fertility-agent-tetanus-vaccine/

    Good news:
    The inactivating drug was recently developed. Temelimab. Interesting that it is anti- MS and Type 1 diabetes since covid triggers those. However, it will not be able to turn off the antibodies to the Syncytin-1.
    https://pubmed.ncbi.nlm.nih.gov/32794123/

  5. Quail says:

    I am truly astonished at how many of my friends have taken the vaccine. They once were vaccine-cautious and tapered their kids shots out with some suspect shots withheld. I thought they would hold back because it is Trump’s vaccine, but they have forgotten all that. Now they happily march up and put out their arms for this experimental one.

  6. jim2 says:

    If one contracts covid, the virus will induce cells to make that very same spike protein, plus a potful of others! So I would think anything triggered by the mRNA vaccine will likewise be triggered by live covid infection.

  7. Quail says:

    In case the vaccine spike shedding turns out to be real- Ivermectin does not block the spike protein in the cell. Stay away from the vaxd.

  8. philjourdan says:

    Here’s the deal. The Pharm companies have immunity (and I agree with that). The responsible party is the Feds. So sue them? Class action? Bidun will just print more money.

    URSCREWED

  9. Quail says:
  10. Nancy & John Hultquist says:

    I have a positive bias. I have never had an issue with a vaccine – polio, tetanus, flu, shingles. I realize things differ.
    Others do have reactions to shots, are prone to allergies, or have other reasons to be leery of vaccines. That’s their misfortune, and I am 100% in favor of their caution. Let me, and other such, get the shots (I’ve had both Pfizer-BioNTech shots without any reactions.)
    Last year, about this time (from this blog and others), I settled on the daily regime of Vitamin D3/red onion/potatoes/beef & multi-vitamin. I also believe in “physical distance” and fresh air.
    I do not believe masks do much good, but wear one when requested; mostly at offices (small closed rooms), and grocery/retail stores where being pleasant is always a good idea. To be honest, I live in a low population region, and I live 8 miles from the nearest town.

    The information presented today is amazingly complex, beyond my understanding. I do appreciate reading it because my brother had Parkinson’s disease, as did another friend.

  11. Jim Masterson says:

    I’ve had both Moderna shots. I guess that means my Alzheimer’s is next. It’s a good thing my mind is still sharp. I can remember my own name—it’s um, er, something or other.

    What’s my name :-(

  12. cdquarles says:

    I recently had an appointment with a hematologist. I am on anticoagulants. One of them is very expensive. If I can, I want to be taken off Eliquis. My cardiologist made the referral to further look into that thromboembolic episode that I had almost 3 years ago (and nearly ended my earthly embodied life). I will hear from him in May, after the massive amount of lab testing is completed.

    We discussed the covid vaccines and that I have had autoimmune illnesses (several, in fact, from scarlet fever to acoustic neuronitis, to ulcerative colitis complicated by pyoderma gangrenosum). I told him that I was wary of the vaccines due to my autoimmune history. He didn’t push it.

    Cardiology people did a carotid and vertebral artery sonogram on me. Just minor narrowing (less than 25% of the diameter) shown so far. Strokes do run in the family. My mom died from complications following multiple strokes. Her elder sister had a massive one that put her in the nursing home (no children). My mom’s mom and my dad’s mom also had strokes.

    After the cluster migraine I had two years ago, my neurologist put me on an acetylcholine esterase inhibitor (nerve poison in high doses) to somewhat counter the effects of valproic acid (seizure medicine in doses higher than I’m taking). Memory issue did show up on aggressive short term memory testing.

  13. E.M.Smith says:

    @C.D.Quarles:

    I’ve become increasingly aware of just how much low levels of Vit-D, C, and such can screw up your health. When my Florida Friend had the heart attack, I went down the rabbit hole and discovered that Vit-C shortage is a major issue in plaque build up, and abnormal clotting in infarctions.

    Then Vit-D is involved in a LOT of things (see that M.D. Video on the other thread. Here:
    https://chiefio.wordpress.com/2021/04/26/wt-is-happening-in-india/#comment-142796 ).

    Also note that diet can change how you clot, with garlic being known to “thin the blood”. You might well find that upping your sun time and having garlic with meals lets you drop a notch on the medications. “Run in the family” can be genetic, or it can be “familial incidence” due to shared environment, food habits, etc. Many of those are things you can change / modulate.

    Note that the dose of Vit-C probably needed per the Gorilla study to prevent heart attacks (and likely strokes) was 2 GRAMS a day. Vit-D to match folks in native African populations is way higher then the “recommendations” too, so for fair skinned folks further south than latitude 35, 20 minutes of sun time is fine; but dark skin and north of 35 folks WILL be Vit-D deficient about 4 to 6 months of the year – with consequences to things like heart attacks, increased cancer risk, etc. I don’t remember where you live (or if you even said) but depending on your location relative to latitude 35, having added Vit-D in winter is necessary, and more so for folks with darker skin color. Oh, and the older you are, the less efficiently you make Vit-D from sun exposure too.

    IIRC the Vit-D discussion in that video mentioned autoimmune / inflammatory processes as a big impact. Also note that SeedOils (corn, soy, etc.) are pro-inflammatory while olive oil, palm oil, coconut oil are not, and omega-3 rich (fish oil, fish, flax) are anti-inflammatory. Your list of “issues” sure looks like inflammatory root cause to me. If you haven’t already, cut out seed oils and only use the others.

  14. jim2 says:

    @Quail https://chiefio.wordpress.com/2021/04/26/truth-or-consequences-or-and/#comment-142801

    I appreciate that the vaccine doesn’t have a long term record and I’m aware there is a possibility that it can go sideways for those of us who have been vaccinated.

    However, the article to which you linked is high on stipulations but low on evidence. Where are the studies that demonstrate shedding? If it does occur, where are the studies that definitively link shedding to an associate getting sick from it?

    Where is the evidence that the vaccine produced spikes more tenaciously bind than the viral spikes? Where is the evidence the fatty micelles can cross the blood-brain barrier.

    I appreciate the ALFD, but this article is over the top.

  15. jim2 says:

    As a follow-on comment about the covid vaccine, why is it that normally skeptical people tend to believe any allegation on the web no matter how unsupported it is by actually studies or other evidence. The more spectacular the claim, the more willing some are to accept it.

  16. cdquarles says:

    I have mentioned where I live several times here. Just say I live near FL :). Noon sun is nearly 20 degrees off zenith now and will be a bit less than 10 degrees off zenith in about 60 days. I get out as much as the weather allows. (Dog must be walked :) or she gets cranky.) Climate zone classification is subtropical (and our epidemic season for corona viruses is summer, not winter).

    About vegetable oils, well in my own case I’m not sure corn oil is pro-inflammatory for me. Grew up with lard and beef tallow, only later did vegetable oil displace it; long after I grew up as a sickly child that caught nearly everything. Some viruses are known to cause autoimmune disease as a later in life complication. It seems to me that this is *way* underappreciated by physicians and the general public. That vegetable oils are pro-inflammatory in others is likely to be true; but as a general state? Of that I am not sure.

    I do take vitamin supplements, a general one plus extra B (folic acid and cyanocobalamin) and D3. I am not keen on large doses of C, for I make oxalate kidney stones. For those that don’t have that issue, sure, take more C. It is relatively harder to overdose on water soluble ones than fat soluble ones; but you can poison yourself with vitamins.

  17. E.M.Smith says:

    @CDQuarles:

    Thanks for the reminder. I tend not to remember where all everyone says they are located. Too much going on to keep track of everyone ;-)

    Yeah, oxalate stones is an issue (spouse…) with Vit-C.

    Per Seed Oils:

    It is fundamental to every one of us. There is ONE enzyme that converts oils to hormone. It produces both an inflammation promoting hormone and an inflammation reducing hormone depending on which fatty acid it converts. The ratio between the 2 is not controlled by any metabolic system, but is instead driven by the competition for the enzyme between the Omega-6 and Omega-3 fatty acids. The ratio of those two directly determines the ratio of pro- vs anti- inflammatory hormone produced.

    Saturated fats like lard (depending on hydrogenation and what the pig was fed), beef tallow, palm oil don’t enter into that picture at all. They do not have an Omega bond in most of their fatty acids. Putting them in the diet is just to displace Omega-6 fatty acids in other oils out of the diet. (Unless the pig / cow was fed a diet high in Omega-6 seeds in which case they will have Omega-6 enriched fats too… Pigs do this a lot, cows to a lesser extent as they get a fair amount of hay / grass for a lot of them).

    Historically, human diet had about a 4 : 1 Omega-6 to Omega-3 ratio. That’s what our system evolved in as the balance point. Current American diet tends to about 22 : 1 (yes, that bad… think about the big push to “polyunsaturated oil”…). So it is truly an inflammation promoting diet in a big way.

    Omega-3 fatty acids are from very limited sources. Basically leaves and things that eat leaves (or the ocean equivalent) and Flax seeds. So it’s hard to increase the Omega-3 level. “Eat Oily Fish” (that ate things that ate seaweed / algae) is nice advice, but farmed salmon has about 1/4 the Omega-3 level of wild salmon as they are fed soybean meal. Bison, grass fed beef, lamb all better 6/3 ratio than Grain Fed Beef, but who knows what’s in that fast food burger… You are what they eat.

    What you can easily do is cut out the oversupply of Omega-6 heavy seed oils. (Harder, but possible, to find eggs from chickens fed flax seeds and grass fed beef so at least you are not getting a big Omega-6 load via what they ate…) It was essentially painless and easy for me to just stop buying corn / soybean / canola oil, and instead buy the big jugs of bland olive oil from the Big Box stores. Doesn’t increase my Omega-3 intake, but really cuts down on the Omega-6 side of the ratio.

    It has helped. It takes time for the body level of Omega-6 oils to be reduced (at least, for pudgy me with excess…) and the ratio to shift, but eventually it has an effect. Unfortunately, even if you move from 22 : 1 down to 10 : 1 that’s still over double where you want to be. So still inflammation promoting. Given that corn and soybeans are the major input to our entire food system, it’s hard to get back to a natural 4 : 1 ratio. But closer is better than far far away.

    We now have ocean fish (preferably not farmed) 2 x week and I will buy high omega-3 eggs when not too expensive. We’re having lamb about 2 x week too. Unfortunately, we’re having grain fed chicken about 3 x a week… but all cooking oils and fats in the house are now saturated fats or olive oil; so neutral to the ratio. It’s helping.

  18. cdquarles says:

    While there is one enzyme here, there is a chain involved, too. In addition, the whole thing is subject to up and down regulation for all enzymes in the chain, including the genes that encode them and the ones used to regulate the genes. Then, there is the inherent individual variation. Embodied life is a very complex and complicated chemical dance. What works for A may not work well for B, or even at all for C.

    A reminder, dose and route make the medicine or the poison. Also, there is no chemical that man can make that the rest of nature can’t. Larger multicellular organisms are comprised of billions to trillions to quadrillions of cells, each containing hundreds or more chemicals; some in common and some not.

    That said, I love fish and shellfish.

  19. YMMV says:

    jim2: “why is it that normally skeptical people tend to believe any allegation on the web”

    Good question. Sometimes people are only skeptical in one direction. sometimes?

    But what caught my attention here was normally skeptical. There is old-fashioned common sense, but other than that I don’t think there are any normally skeptical people. With the exception of some scientists and Spock-type autistics… It is a learned thing, an acquired taste. And modern tastes are for political, not skeptical. And the education system has failed.

  20. jim2 says:

    YMMV – I believe it is safe to say the denizens of this site are more skeptical than the average Joe. That’s what I meant by normally skeptical. I believe most here are skeptical that global warming is a problem. I know I am. I have a scientific background and I consider myself skeptical. Perhaps I should have said people who are normally skeptical. Yeah, that’s the ticket!

    One thing I was convinced of is that getting COVID is a very bad thing for me, given my age, medical circumstances, etc. So, I rolled the dice on the vaccine.

    If I do get COVID anyway, there’s always ivermectin. I just hope I ‘get there in time.’

    In the meantime, hospitalization rates for my age group is way down. So, hopefully I won’t end up with COVID in the first place.

    https://gis.cdc.gov/grasp/COVIDNet/COVID19_3.html

  21. philjourdan says:

    @EMS
    I tend not to remember where all everyone says they are located. Too much going on to keep track of everyone ;-

    Remember me saying I lived in the north pole?

  22. philjourdan says:

    @jim2 – No dice for me. Just a nagging wife. Who if she had not nagged. I would be fully vacinated Tuesday instead on in 3 weeks!

  23. E.M.Smith says:

    @YMMV:

    “With the exception of some scientists and Spock-type autistics… ”

    Made me chuckle… “I resemble that remark!”

    I don’t consider myself a “skeptic”. I consider myself a logic engine. I just assemble the logic syllogism and compare inputs to conclusions. IF the conclusion is unsupported, it is not “true”. End of syllogism.

    Something about taking formal logic training in school at a sensitive moment in my life ;-)
    Oh, and a good 48 years programming computers… Kind of forces you into a logic driven absolutism of sorts…

    I don’t believe. I don’t dis-believe. I ask what data exists, what relationships are proven, and solve. You either get TRUE or FALSE or INSUFFICIENT.

    Oh, and Spock was my Idol ;-)

    @CDQuarles:

    Oh, uh, yeah, that stuff ;-)

    (Another one where IF I go into all of it I get called Prolix and “Walking Encyclopedia” and if I skip over it all to the one big point, I get remanded for skipping important information. Some Day I’ll find just the right point where everyone is happy ;-) /sarc;

    @Jim2:

    I replied to that comment, but on another thread… (It’s been that kind of day…)

    WT? Is Happening In India?

    @PhilJourdan:

    IN the North Pole? Isn’t that rather a small home?

    sniggle… ;-)

    Take what comfort you can from knowing that the J&J vaccine with one dose is about the same immunity as the first dose of the 2 parter. 60-something percent. You get the next 25% with your 2nd dose…

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