S1 Spike Protein Lung Injury & Long Covid / Long Vaccination Symptoms

A couple of Dr.Been videos pointed me at the S1 Spike Protein being causal of Long Covid and directly involved in lung injury. In the lung injury case, mice with a humanized ACE2 were dosed with S1 Spike units and developed lung injury. The implication here is that some folks getting the vaccine may also react similarly.

Then, in Long Covid, another group of doctors have found that the S1 protein expressed on the surface of a monocyte is likely responsible for Long Covid. They mentioned a similar syndrome post vaccination where some folks have a long duration of feeling off, and that this was likely the same mechanism.

The claim is made that they now have an effective treatment for Long Covid.

https://www.healthrising.org/blog/2021/07/21/patterson-cracked-long-covid/

Has Bruce Patterson Cracked Long COVID?
by Cort Johnson | Jul 21, 2021 | Homepage, long COVID

Bruce Patterson MD is a former Stanford researcher with quite a record. The former Medical Director of Diagnostic Virology at Stanford University Hospitals and Clinics, Patterson has co-authored around 90 papers – most prior to 2011 – at about the time he left the University and created the incellDx diagnostic laboratory. Over the past ten years, incellDx has focused mostly on cancer screening and has produced products to test for HPV, CMV, antibodies, and others. Over the past two years, though, Patterson has jumped back into the publication field, co-authoring 7 papers on COVID-19 with more to come.

In June of 2020, Patterson reported that he’d identified the cause of the so-called “cytokine storm” in COVID-19.

“When we were developing a cytokine quantification assay for possible COVID trials in China, we discovered that infected patients had consistently high levels of CCL5/RANTES in plasma which in some cases was 100 times normal depending on the severity of the disease.”

Patterson and incellDx filed a patent in June 2020 for its CCL5/RANTES diagnostic test for COVID-19, Patterson reported. In October, incellDx reported that it was collaborating on a COVID-19 clinical trial using Pfizer’s CCR5 antagonist Maraviroc – a key part of Patterson’s long-COVID protocol.

Patterson is all over social media. His YouTube interviews and presentations have garnered over 400,000 views over the past year. ABC News just led with a story: “EXCLUSIVE: Lab discovers root cause of confusion, fatigue experienced by COVID ‘long haulers‘

Patterson has become a kind of a sensation … and why not? He’s credible, claims to be studying the largest cohort of long haulers (thousands) in existence, and believes that not only has he found the cause of long COVID, but that he’s put together a treatment regimen that works. No new drugs are needed – everything is off the shelf. It almost couldn’t be better.

How excited are people? One doctor on YouTube is so sure that Patterson has got it right that he recommended that he be nominated for a Nobel Prize. That’s a bit much for a hypothesis and treatment regimen which hasn’t been independently validated yet, but it does portray some of the excitement Patterson has generated.

Patterson, incellDX and the Coronavirus

As noted, it all began in the summer of 2020 when Patterson and incellDX found abnormal levels of cytokines – signaling fire in the body. Patterson’s first COVID-19 paper in May 2020 found a “profound elevation of plasma IL-6 and CCL5 (RANTES)” in 10 critically ill COVID-19 patients. It was followed in January 2021 by a paper showing that a COVID patient with a poor T-cell response was still shedding the virus 90 days after becoming infected. Next, Patterson and his team found that a CCL5 blocker called leronlimab might be a good drug to try in COVID.

Patterson’s two major papers, “Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning“, and “Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection” – the second an unreviewed preprint – showed up in June of this year.

Immune Cells and Cytokines

On the face of it, the first paper didn’t seem revolutionary at all. This type of study – which assessed the immune cell subsets and 14 cytokines – has been done many times in chronic fatigue syndrome (ME/CFS). (In a talk, Patterson noted that he’d winnowed down the cytokines from about 150 possible factors to 14.) The study involved a mishmash of 224 acute COVID-19 and long-haul COVID-19 patients and 24 healthy controls.

The study found that CCL5/RANTES, IL-2, IL-4, CCL3, IL-6, IL-10, IFN-γ, and VEGF were all significantly elevated (all P<0.001) while GM-CSF and CCL4 were significantly reduced in COVID patients in general.

Next, they used machine learning to develop immunotypes pertaining to each type of COVID patient and found long-haul COVID patients were characterized by increased IFN-γ and IL-2, and reduced CCL4 production.
[…]

skipping down a bit it is the “2nd Paper” that’s what this posting is about:

The second paper, “Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection“, tied their hypothesis together.

As noted, it wasn’t just the monocytes – it was a particular kind of monocyte – that was increased in both acute and long COVID-19.

First, the group looked for evidence that COVID-19 had infected the monocytes in both acute and long-COVID patients and found evidence of some infection but not a lot. COVID-19 replication does not appear to be the problem.

When they used antibodies to look for evidence of coronavirus proteins in the monocytes, though, they found them – in spades. Seventy-three percent of the “non-classical” monocytes in long-COVID patients carried the coronavirus proteins.
(They used another test – Ultra-High-Performance Liquid Chromatography – to largely confirm the results.)

These types of monocytes have often been thought to be anti-inflammatory, but recent studies show that they can, in some situations, produce pro-inflammatory cytokines. They’re mostly involved in “trash cleanup”, and the antiviral response. Interestingly, they appear to be unique in the patrolling behavior they exhibit around the blood vessels.

The authors believe these monocytes were drawn to coronavirus-infected cells in the blood vessels, where they ingested them, and then put a coronavirus protein on their surface to alert the immune system. The problem in long COVID occurs when they are drawn to the blood vessels and injure them, or cause the blood vessels to inappropriately dilate.

These nonclassical monocytes are the only monocytes to carry the CX3CR1 receptor, which when it binds to fractalkine, turns on an anti-apoptotic protein that allows the monocytes to survive longer than usual. It also causes the monocytes to revert from their anti-inflammatory state, and start pumping out pro-inflammatory cytokines.

These are important steps as most monocytes die within a few days, and having very long-lived (up to at least 16 months) coronavirus protein-carrying monocytes is a crucial aspect of Patterson’s hypothesis. Patterson also needs these monocytes to attack the blood vessel walls.

CX3CR1 is also an important player in getting the monocytes to engage in their vascular patrols, and deleting CX3CR1 has been shown to reduce their patrolling behavior.

Monocytes carrying the SARS protein and endothelial cells are producing high levels of CCL5/RANTES – a chemokine that draws the monocytes cells to the endothelial cells. Patterson reported that CCL5/RANTES was upregulated in 80% of long haulers. Once at the endothelial cells, the monocytes bind to them via fractalkine – a kind of immune Velcro.

There’s more at the link about mechanism. Let’s skip on down to treatment:

Treating

Successfully treating long COVID is. Patterson, an MD, reported that they started treating long-COVID patients in September 2020. Patterson’s protocol has two main goals:

Use CCR5 antagonists to reduce CCL5/RANTES levels, and therefore prevent the monocytes from getting to the blood vessels.
Damp down the CX3CR1/fractalkine pathway in order to turn off the long term monocyte survival mechanism that’s allowing them to survive longer than usual. Over time, the monocytes carrying the coronavirus protein will die off.

The Protocol

The treatment protocol is remarkably brief – just 4-6 weeks
. First, immune labs are taken and then 3 drugs are given. (The fact that none of these drugs have been used in ME/CFS should remind us how vast the medical drug toolkit is and how many possibilities it holds.)

Drugs

CCR5 antagonist – Maraviroc (Selzentry (US), Celsentri (EU)) is in an antiretroviral drug used in combination with other drugs to treat HIV. (HIV can use the CCR5 receptor to enter the cell). Its efficacy against the coronavirus is also being explored. Maraviroc also stops monocytes from moving around the body in response to CCL5/RANTES – a chemokine which is produced in endothelial cells. Maraviroc comes with plenty of warnings, including a black box one, but Patterson says its is safe – and has two papers coming out on it. Most long haulers are on for 2-4 weeks and the longest has been 8 weeks. Maraviroc, he said, was incredibly effective in relieving tinnitus and brain fog and typically did do so in 3-5 days. He said “we see it (tinnitus) a lot, and treat it a lot and are very good at eliminating it.”

Statins – by inhibiting fracktalkine, it stops the monocyte cells from attaching to endothelial cells on the blood vessels.

Ivermectin -an immunomodulator and anti-parasitic drug is used because of its persistent antiviral properties.
It also affects cell membranes. A meta-review of 11 randomized Ivermectin COVID-19 trials found a significant reduction in hospitalization and and 56% reduction in death. Many of the trials were not peer-reviewed, and a wide range of doses was used. A placebo-controlled Ivermectin COVID-19 study is underway at the University of Oxford.

Here’s the Dr. Been Videos.

Some of Dr. Been’s audio is a bit garbled, but the rest is fine. This is the one about Long Haulers. One hour, 24 minutes:

Spike Proteins In Immune Cells – Dr. Bruce Patterson Discusses COVID Long Haul
567,348 views Streamed live on Jun 25, 2021

Drbeen Medical Lectures

Dr. Bruce Patterson’s team has discovered that the S1 pieces of the spike proteins persist in the monocytes resulting in immune dysregulation and long-haul syndrome. Let’s discuss these findings with him.

Dr. Patterson’s site: https://covidlonghaulers.com/

Then the other video on how the S1 Spike bit causes lung injury in mice which human ACE2 enzyme. 26 minutes:

Researchers Show How SARS-COV-2 Spike Protein Causes Acute Lung Injury in Mice
137,347 views Streamed live on Sep 1, 2021

Drbeen Medical Lectures

First study in mice demonstrates that S1 part of the spike protein in combination with hACE2 enzyme triggers cytokine like storm and acute lung injury. Let’s review this study.

Study:https://journals.physiology.org/doi/full/10.1152/ajplung.00223.2021
Study PDF:https://journals.physiology.org/doi/pdf/10.1152/ajplung.00223.2021

Long Haul Post Vaccine?

I’d not heard of “Post Vaccine Long Haul” but it looks like for some folks “it’s a thing”:

https://newsrescue.com/long-haul-post-vaxx-syndrome/

Long Haul Post-Vaccine Syndrome: Share Your Experience
By Dr. Brimah -August 17, 2021

NewsRescue

by Dr. Perry Brimah M.D., M.S. Twitter: @DrPerryBrimah

SUMMARY

Long haul post-vaccine syndrome deals with a variety of symptoms that have been reported post Covid-19 vaccine. Some patients are reported to have presented with symptoms which resemble acute Covid-19 infections and others have presented with symptoms seen in patients suffering from Long haul Covid. Long haul post-vaccine syndrome may present in patients several months after taking Covid vaccine shots. According to leading physicians dealing with the syndrome, it is manageable and is treated similar to Long haul Covid. The suspected culprit in both syndromes is the ‘spike protein.’

Covid Virus Spike Protein

Covid-19 virus’ pathogenicity is courtesy of its spike protein. Upon entrance into the body, the spike protein attaches to ACE2 (angiotensin converting enzyme 2) receptors in the cell membranes (Pillay, 2020). ACE2 receptors of epithelial cells lining the airways are a first target of the virus upon inhalation. Upon attachment, the spike protein gets activated and changes from a ‘pre-fusion’ shape to a ‘post-fusion’ state where it is like a spear that pokes through the cell membrane and allows the viral genetic material entrance to your cells to replicate.
[…]
Long Haul Covid

Long haul covid or Long-COVID or COVID long-haulers according to a new review can present with as many as 55 long term symptoms. The most common of which are “fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%)…Diseases such as stroke and diabetes mellitus were also present.” Psychiatric problems like dementia and insomnia are also included. Smell and taste deficiency may persist as also cough and lung abnormalities. Autoimmune problems where the body fights itself is also part of this plethora of presentations. Weight loss, palpitations, renal failure, mood disorders, throat pain and sputum, myocarditis, arrhythmia, OCD, intermittent fever, digestive problems are some more.

The precise cause of Long-COVID and Long-Post-Vaccine is being investigated but it may be due to organ damage or persistent autoimmune or inflammatory damage after the infection. Another recent study found Epstein Bar virus reactivated in 73% of long haulers and blamed this for the chronic fatigue, raynaud’s phenomenon and other related symptoms.

I’ve seen an assertion that post vaccination various endogenous suppressed viruses are able to reactivate. Shingles outbreaks, for example.

IF In fact Long Covid is due to just the S1 protein on monocytes, and both the vaccine and the disease can cause that to happen, then being vaccinated alone will be a big problem for some folks.

I note in passing that Robert Felix of Iceagenow.com / Iceagenow.info died after a sudden resurgence of an autoimmune illness that had been in remission, and that this started about 2 months after he was vaccinated. He did not believe his illness was related, due to the passage of many weeks after the vaccination. But not all reactions are immediate… It looks like his web site is now gone, but I found a copy on the Wayback Machine: http://web.archive.org/web/20210828042903/https://iceagenow.info/

All Cause Mortality numbers must be compared pre and post vaccination campaigns to have any clue how much damage is being done by turning people into S1 Spike Protein factories.

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About E.M.Smith

A technical managerial sort interested in things from Stonehenge to computer science. My present "hot buttons' are the mythology of Climate Change and ancient metrology; but things change...
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30 Responses to S1 Spike Protein Lung Injury & Long Covid / Long Vaccination Symptoms

  1. cdquarles says:

    Well, that’s very interesting.

  2. jim2 says:

    If that’s all true, then one should, possibly, be able to analyze blood samples from the dead to see if the spike-monocyte, or pieces of them, are present. Might be a quick way to determine if covid or vax played a part in death.

  3. E.M.Smith says:

    @CDQuarles:

    I was hoping it was something you would like ;-)

    @Jim2:

    Equally interesting is the question of why a few have that issue, and many folks just get the bug or the jab and No Bad Thing happens.

    I’ve love to have a method to determine if my worries about auto-immune over reaction were valid, or just silly. But we don’t have that so I’m left with a pair of loaded dice to roll. (Either way could be worse for me IFF I react badly to the S1 unit… so I’m left with hoping the prophylactic approach works until they figure out how to do a vaccine that is better…)

    Oh Well… we needed someone in the “control group” anyway 8-)

    FWIW, I have no idea what happens to monocytes and the protein bits they express after one dies. Some stuff goes away rapidly, other stuff you can re-autopsy decades to centuries later, and I don’t know which is which beyond what I’ve seen watching Bones on T.V. ;-)

  4. jim2 says:

    I’m just happy my onions are intact :)

    Based on what I know now, I won’t be getting a booster. Like you say, it would be nice to have some predictor about heart or other problems. It might be deterministic, or not.

  5. Power Grab says:

    Re Robert Felix:

    I have read lots of reports from people who post on Twitter (I know, I know…but I have considerable faith in my BS detector) that their past illnesses (that had been “cured”) manifested again after they were jabbed.

    Did I tell my story here about how the probiotic Yakult helped me stop reacting to wheat? Before taking it, if I ate food made from wheat (especially if it wasn’t organic), then I had to stay close to the bathroom for 3 days.

    I also started avoiding tap water that contains chloramine (chlorine + ammonia) and switched to either spring water or well water.

    While keeping up with both of those changes, I now can eat pretty much anything without having to spend 3 days close to the bathroom.

    There’s more to the story, but I shouldn’t try to tell it right now.

  6. John S Howard Jr says:

    My sis in law was pretty draggy with a low grade fever and generally not feeling well. She decided that she possibly had the “long COVID” and began an Ivermectin Protocol. She was amazed that in about three days she began to feel like her old self again.

  7. David A says:

    EM says…
    “Equally interesting is the question of why a few have that issue, and many folks just get the bug or the jab and No Bad Thing happens.
    I’ve love to have a method to determine if my worries about auto-immune over reaction were valid, or just silly.”

    Just some cogent thoughts…. hopefully useful and not to redundant to all that you know.

    https://theexpose.uk/2021/09/22/why-covid-booster-shots-are-uniquely-dangerous/

    “repeatedly boosting the immune response will repeatedly boost the intensity of self-to-self attack.” – Doctors for COVID Ethics”

    Doctors for COVID Ethics are doctors and scientists from 30 countries, seeking to uphold medical ethics, patient safety and human rights in response to Covid-19.  Below are extracts from their comprehensive analysis: The Dangers of Covid-19 Booster Shots and Vaccines: Boosting Blood Clots and Leaky Vessels which we encourage all doctors and patients to read before promoting, delivering or accepting any further Covid injections.”

    “Booster shots are uniquely dangerous, in a way that is unprecedented in the history of vaccines.  This is because repeatedly boosting the immune response will repeatedly boost the intensity of self-to-self or autoimmune attack, including boosting complement-mediated damage to vessel walls.

    In addition to autoimmune attacks, antibodies to coronaviruses can enhance the severity of wild, or naturally occurring, coronavirus infection. This is called antibody-dependent enhancement of disease”

    So my take is pre-existing natural immunity ( 90 percent show robust memory production of antibodies to Covid 19) increases the chance of ADE or perhaps OAS happening in response to Covid and possibly the vaccines as well.

    From the third link in this post…

    “The good news is that we are more comprehensively protected against COVID-19 by our own pre-existing immunity than was previously understood. On the other hand, this pre-existing immunity aggravates the risk that COVID-19 vaccines will induce blood clotting and/or leaky blood vessels. This risk must be expected to escalate with each revaccination. Vaccine-induced harm to our blood vessels is unlikely to be rare.

    Perhaps the most pertinent finding is that, due to the discovery of a widespread memory-type antibody response to SARS-CoV-2, the antibodies induced by the COVID-19 vaccines can be expected to activate the so-called complement system. This can bring about the destruction of any cell that manufactures the SARS-CoV-2 spike protein, particularly in the circulation. If that happens to the endothelia, that is, the cell layer that lines the inner surfaces of our blood vessels, then those vessels may begin to leak and clots will form. Given that 2021 research showed the spike protein to enter the bloodstream shortly after vaccination , this dangerous endothelial involvement in spike-production is highly likely, and should be expected to occur.

    As stark as these medical realities may be, the silver lining is that the same antibody profile, along with previously documented T-cell immunity [7–11], protects around 99% of the population against life- threatening SARS-CoV-2 infections. This ties in with the known fact that over 99% of people are safe from death with COVID-19 [12–14]. The implications for doctors and patients are that:

    1. Vaccination against COVID-19 is unnecessary. Populations are protected by their immune systems against COVID-19. This applies to SARS-CoV-2 in all its variants.

    2. Booster shots are uniquely dangerous, in a way that is unprecedented in the history of vaccines. This is because repeatedly boosting the immune response will repeatedly boost the intensity of self-to-self attack.

    An important consideration for patients is that those who have already been vaccinated against COVID- 19, and whose health remains intact, can protect themselves against serious harm by stopping now.

    For a detailed explanation of the science behind these vaccine-immune interactions, please read Part II. Implications for doctors and patients are considered in Part III.
    2. In Full: Explanation of New Findings on the Immunology…

    So my thought is you are spot on…

  8. David A says:

    EM sorry for the resin you in the above post.

    Here is the link to more details…
    Link:https://doctors4covidethics.org/wp-content/uploads/2021/09/Vaccine-immune-interactions-and-booster-shots_Sep-2021.pdf

  9. David A says:

    Arg sorry for the repetitive sections of the long post

  10. David A says:

    Oh well, copying link but the above partial print from the destination appears

    [Reply:WordPress decided it would “help” by displaying embedded PDF files. Put text like Link: in front of it to stop that. -E.M.S.]

  11. H.R. says:

    @David A – ??? There’s a scroll bar on the right of the image that first appears, so what you have is the whole 11-page document.

    I’m not sure what you meant by a “partial print.” Seems like the whole enchilada to me.

  12. David A says:

    Thanks !

  13. David A says:

    Weird though, no scroll bar for me.

  14. Sandy McClintock says:

    I know several people with a mystery condition known by several names like Chronic Fatigue Syndrome (CFS or ME). Their symptoms sound rather similar to Long Hauler COVID. Many people with CFS say it started with a viral infection. Let’s hope that there will be some new light shed on these conditions – and perhaps a cure. Might even be ivermectin ?

  15. E.M.Smith says:

    @Dave A:

    I’ll do some “fix up”.

    Some browsers show a scroll bar, others do the “grab and slide” without scroll bars. Tablets with touch screens especially differ from 1 button, 2 button, 3 button and scroll wheel mice in how programmers chose to show “features”.

    Worpress now chooses to display a sample / whole thing of some links instead of just the link text. I put “Link:” in front of pdfs and such to get just the link.

    BTW, felt no “resin” ;-) It was useful new information. I had imaginings, now I know others are thinking that too.

  16. Ossqss says:

    You guys need newer software.Just sayin… Check your vintage.

  17. jim2 says:


    (Bloomberg) — When Catherine Moring, president of Mississippi’s Public Health Association, tested positive for Covid-19, she turned to ivermectin to keep her safe.

    Moring, who is executive director of a wellness center at Tallahatchie General Hospital in the town of Charleston, said she isn’t against inoculations in general, but believes Covid vaccines present unnecessary risks. She went to a group called Front Line Covid-19 Critical Care Alliance for help getting an ivermectin prescription.

    “I’ve had a lot of friends take it, because Covid is everywhere right now,” Moring said. “I felt very comfortable with the studies that I’ve read.”

    Millions of Americans are following the same path. Outpatient ivermectin prescriptions rose more than 24-fold from prepandemic levels to 88,000 a week in the seven days ending Aug. 13. There have been about 1.2 million retail prescriptions written this year for the drug, compared with 340,000 in 2020, according to data provider Symphony Health.

    https://www.msn.com/en-us/money/other/ivermectin-advocates-push-online-for-using-unproven-covid-drug/ar-AAOMkrG

  18. AC Osborn says:

    Sandy McClintock says: 24 September 2021 at 3:05 am
    Also Fibromyalga.

  19. David A says:

    AC, do you have any information on fibromyalgia and Ivermectin? My wife has had it bad for years.

    @EM, glad the link was useful. The link inside the link https://doctors4covidethics.org/wp-content/uploads/2021/09/Vaccine-immune-interactions-and-booster-shots_Sep-2021.pdf

    give more supported weight behind the concerns.

  20. jim2 says:

    I feel pretty good about the collection of science-based journal papers we have amassed here. I feel like it has been credibly demonstrated that the vaccine can cause severe problems which even if it doesn’t kill, can maim potentially for years. And I feel it has been credibly demonstrated that IVM is the go-to treatment for Covid-19 – along with a whole host of other drugs.

    I never doubted the government is criminally lying, so I didn’t really need proof of that.

  21. David A says:

    “ I never doubted the government is criminally lying, so I didn’t really need proof of that”

    Sad but true. I wish the prior paragraph was wrong, and have noted my own tendency to block from conscious reflective contemplation the realties the evidence presents. What was that Three Dog Night song;

    Interesting the song says, especially people that care about social injustice.. the mantra of today’s left, and the attempt to portray all of the right as heartless racist etc…

    And another where the lyrics go, “If I knew I wouldn’t even want to say”.
    Can’t remember the title for that one.

  22. David A says:

    Ah, the other song is Loggins and Messina
    Peace of mind;

    “But blessed be the one who can understand why
    People have to act that way
    ‘Cause if I knew I wouldn’t even want to say

    But have a little peace, just a little peace of mind
    Give me some peace, yeah, peace of mind”

  23. E.M.Smith says:

    @David A:

    You might be interested in this, then (It has a huge cookie banner so I’m quoting heavily):

    https://www.webmd.com/fibromyalgia/news/20190516/scientists-spot-unexpected-player-in-fibromyalgia

    Scientists Spot Unexpected Player in Fibromyalgia

    FROM THE WEBMD ARCHIVES

    By Serena Gordon HealthDay Reporter

    THURSDAY, May 16, 2019 (HealthDay News) — Fibromyalgia is a mysterious and misunderstood illness, but researchers may have uncovered at least one key to the disease’s origin: insulin resistance.The new research compared a small group of people with fibromyalgia to two groups of healthy people and noted that a long-term measure of blood sugar levels was higher in the people with fibromyalgia. Insulin resistance develops when the body starts to struggle with breaking down sugar.To see if treating those higher blood sugar levels might help, the researchers gave people who had blood sugar levels in the pre-diabetic range or higher a diabetes medication called metformin. People taking metformin reported significantly lower pain scores, according to the study.”We combined metformin with standard drugs used for fibromyalgia and saw a much greater degree of pain relief,” said study author Dr. Miguel Pappolla. He is a professor of neurology at the University of Texas Medical Branch at Galveston.

    In fact, Pappolla said, the additional pain relief was so significant that the researchers actually called patients on different days to re-check their pain scores.

    Because this is a preliminary finding, the researchers aren’t sure how insulin resistance might contribute to fibromyalgia or how metformin might reduce pain. “Metformin may have some analgesic [pain-relieving] activity on its own,” Pappolla said.Fibromyalgia is a condition that causes widespread pain, fatigue, sleep problems and distress, according to the U.S. Centers for Disease Control and Prevention. Even celebrities aren’t spared from this painful condition — Lady Gaga reportedly had to cancel concerts on her tour due to pain from fibromyalgia.

    Though the cause of the disorder isn’t clear, it appears that people with fibromyalgia may be more sensitive to pain than other people — what the CDC calls abnormal pain processing.

    Pappolla said that studies have shown differences in the brain between people with fibromyalgia and those without, such as areas with a lower blood flow than expected. The researchers noted that similar problems have been seen in people with diabetes.The study included 23 people with fibromyalgia. The researchers compared their hemoglobin A1c levels to large groups of healthy people from two other studies. Hemoglobin A1c is a simple blood test that measures what someone’s blood sugar levels were during the past two or three months. A level of 5.7% to 6.4% is considered pre-diabetes, according to the American Diabetes Association. A level of 6.5% or higher means a person has diabetes.

    Only six of those with fibromyalgia had normal blood sugar levels. Sixteen had levels considered pre-diabetes and one met the criteria for diabetes.

    When the researchers compared the average blood sugar levels of the fibromyalgia group to healthy age-matched people in the other studies, they saw that the blood sugar levels were higher in the people with fibromyalgia, suggesting insulin resistance.

    The findings were published online recently in the journal PLOS ONE.

    Dr. Edward Rubin, an anesthesiologist and pain management specialist at Long Island Jewish Medical Center, said, “It’s interesting that there’s a possible connection between fibromyalgia and blood sugar. We’ve been attacking the symptoms of fibromyalgia, but we don’t have a good understanding of the root cause of fibromyalgia.”

    Rubin, who wasn’t involved in the study, said there may be enough evidence here to try metformin along with other medications used for fibromyalgia for people whose blood sugar levels fall outside of the normal range, to see if they have a positive response.

    Dr. Bharat Kumar, from the University of Iowa Hospitals and Clinics, said this study shows people with the disease that there is hope.

    “People with fibromyalgia are often told [falsely] that they have a disease that simply cannot be managed. This article shows that it’s not true. Although it’s unclear if metformin will work for every person suffering from fibromyalgia, there is active research into finding solutions for this frustrating and overlooked condition,” he said.

    Kumar said it’s biologically plausible that insulin could have an effect on pain. “We know that other hormone abnormalities can cause fibromyalgia-like symptoms, so [this finding] is not too surprising,” he added.

    Still, he said, he didn’t expect that metformin would be a “silver bullet” for all fibromyalgia pain. He said there are likely a number of causes of the disease.

  24. E.M.Smith says:

    @Jim2:

    I’m also pretty comfortable with the (scattered all over dozens of postings and hundreds of comments) citations, papers, and more that’s been dug up and documented.

    Most pleasing to me is that it looks more like a “All Work” than a “no hope”.

    The various vaccines work to greater or lesser degree, but so far only for a limited duration.

    They do create / foster “variant” that escape the vaccine, but so far with lesser illness on infection. (There is a Big Gray Cloud about the Jabbed & Dieing being counted as UN_vaccinated until 2 weeks after the 2nd jab and potentially months after their first… so subject to change on this one if we can ever unscramble those eggs…)

    Ivermectin seems to do a great job of prophylaxis and is a pretty good treatement.
    Monoclonal antibodies are a pretty good treatement.
    Zinc Ionophores with Zinc is a pretty good treatment (Quinine, Hydroxychloroquine, Quercetin)
    Some of the other -mectin related show promise.
    Doxycycline / Azithromycin / Levofloxicin look to be helpful treatments.

    And now we’ve got brochodialators and antihistamines as helpful / antiviral treatments.
    Link:https://chiefio.wordpress.com/2021/09/03/w-o-o-d-3-september-2021/#comment-151089

    It’s getting to where we need to write up a Summary Posting Of CURES for Chinese Wuhan Covid just to keep them all straight…

  25. AC Osborn says:

    David A says 24 September 2021 at 1:24 pm

    “AC, do you have any information on fibromyalgia and Ivermectin? My wife has had it bad for years.”

    Sorry, I don’t. My son is in his 3rd year with it. I did read that Naicin helps, but he hasn’t tried that.
    What did help a bit was boosting his very low Vitamin B12. Only noticed by an old Doctor in a private consultation, his doctors and the hospital missed it altogether.

  26. jim2 says:

    There is a bitter-sweet irony in this – delicious.

    Hawk Newsome, the co-founder and chairman of Black Lives Matter of Greater New York (BLMGNY), argues the mandates are fundamentally racist, given the low rate of vaccination in the black community.

    Some 85.6 percent of black people in the state of New York remain without one dose of the COVID-19 vaccine, according to state data.

    “I think, in a perfect world, [vaccine requirements] should be business by business. But it could be a slippery slope, so the mandate should be removed completely,” Newsome told the Washington Examiner.

    “It’s not gonna be white men in suits on Wall Street who are gonna get stopped. There’s such hypocrisy in this thing.”

    https://www.breitbart.com/politics/2021/09/24/black-lives-matter-leader-calls-vaccine-mandates-racist-promises-uprising-against-id-system/

  27. E.M.Smith says:

    I love this 10 minutes of 2 Black Guys With CLUE just ripping the present Death Mandates from the Drug Companies:

  28. E.M.Smith says:

    Oh, I like this list of “rules of thumb”:

    https://richardsonpost.com/howellwoltz/22924/and-the-fully-vaccinated-rock-of-gibraltar-crumbles/

    SO HERE’S A RULE OF THUMB….

    If Media hacks, compromised officials, Big Pharma, Big Tech Censors, Globalists and Marxist are all singing in unison—then you know whatever they’re singing about is a damn lie and meant to harm you, so start breaking it apart and examining everything.

    If Media exhorts a narrative in unison—you can be sure it’s false.

    If these hack leaders try to force it on you—then it’s no good, don’t do it.

    If Big Pharma is behind it—it’s not about (or good for) you.

    If Big Tech won’t allow questions—then the narrative is fake.

    If the Globalists are for it—then it is pure evil.

    If the Marxists are in favour of it—then you should fight it to the death.

    The rest of the article is largely a comparison of nearly 100% jabbed Gibraltar with the Free Nation Of Sweden and how Swedes are doing fine while in Gibraltar (the article they quote from):

    https://bigleaguepolitics.com/fully-vaxxed-gibraltar-sees-2500-percent-spike-in-covid-19-cases-per-day-initiates-new-lockdowns/

    Fully-Vaxxed Gibraltar Sees 2500 PERCENT SPIKE in COVID-19 Cases Per Day, Initiates New Lockdowns

    Shane Trejo Aug 4, 2021

    As they point out: Who will you blame that on when nearly everyone is vaxxed? Eh?

    IT is a “plague of the vaxxed” and you can not deny it.

  29. The True Nolan says:

    ANY impartial observer would have to judge Jonathan Isaac to be a calm, rational, well spoken and well informed person, fully capable of deciding for himself whether to take an experimental gene therapy. Kudos to him. His fault in the eyes of the MSM and Rolling Stone? He has left the plantation, and now he is “acting uppity”. How dare he think for himself?!

  30. The True Nolan says:

    It is important to remember that statistics are more than just numbers.
    https://obits.oregonlive.com/us/obituaries/oregon/name/jessica-wilson-obituary?pid=200278331

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