This video surprised me, in several ways.
First, I was looking for some distraction from current events, and I got a reminder of them (along with some usable clue – A leaky vaccine is likely to leave the “jabbed” with Original Antigenic Sin to later variants).
Second, I was not expecting At All the actual origin of the “Spanish Flu” that was found. It came from horses in North America.
Third, I expected a dry technical lecture, I got a fascinating story or two about humanity. Plus a chuckle about German Cowboys invading Canada…
Forth, I thought I knew why 20-30 year old folks died the most. Cytokine Storm from a young and well working immune system. That’s wrong. It was a case of Original Antigenic Sin.
Fifth, I had no idea that the round of H1N1 flu from a few years back was a Lab Leak, most likely from China or Russia, yet its genetic clock was stopped at 1950…
Sixth, What beats mutating viruses with low efficacy vaccines is therapeutics.
Plus a few more…
Well worth the watching of it. Given the nature of Original Antigenic Sin, I suspect that for Chinese Wuhan Covid it will be the case that the first antibodies you make are the ones you will most likely have for life. Once the virus changes enough, they will do little, and then you have a Very Bad Case. It is possible that Covid is unlike Flu in that we make antibodies to the H and N projections of flu, and the body of Covid plus the spike; so there is still a small chance of what I’d call “antibody stacking” with adding more over time. But the example of Original Antigenic Sin in the flu leans the other way.
The other conclusion is that, yes, a leaky vaccine selects for variants that escape the vaccine (and the vaccine antibodies) but IF Original Antigenic Sin is happening with Chinese Wuhan Covid, we would likely still get there anyway. Just a lot slower. It will all come down to how effectively folks make antibodies to the N capsule parts of the virus, IMHO.
I’m also looking at the Flu Vaccine as being not very useful to me. I likely have been exposed to the two major variations already. This video is from 2014, or 7 years ago, which puts me in a cohort who was originally exposed to the 1957 strain, but also has been exposed to H1N1 (and likely a couple of others). My immune system has already made its choices and a jab is unlikely to change them. That may be why I’ve not had the flu in about 30 years and had zero reaction to the one flu shot I got about 5 years ago. I’m just “so over it” ;-)
The number killed each year by flu also shouts “What the he.. happened to the Flu last year?”…
One hour and 8 minutes:
The University of Arizona
Michael Worobey, Professor, Ecology and Evolutionary Biology, The University of Arizona
The Spanish influenza pandemic of 1918 was the most intense outbreak of disease in human history. It killed upwards of 50 million people (most in a six-week period) casting a long shadow of fear and mystery: nearly a century later, scientists have been unable to explain why, unlike all other influenza outbreaks, it killed young adults in huge numbers. I will describe how analyses of large numbers of influenza virus genomes are revealing the pathway traveled by the genes of this virus before it exploded in 1918. What emerges is a surprising tale with many players and plot lines, in which echoes of prior pandemics, imprinted in the immune responses of those alive in 1918, set the stage for the catastrophe. I will also discuss how resolving the mysteries of 1918 could help to prevent future pandemics and to control seasonal influenza, which quietly kills millions more every decade.