Ivermectin & Doxycycline 98% Cure

The video also mentions another antimalarial that is also looking like it works. Tefenoquine. More on that below, but first, Ivermectin.

In use in Bangladesh, Ivermectin with Doxycyline given early has 98% success at curing Chinese Wuhan Covid-19 in over 400 patients in 4 to 14 days. Some with comorbidities did go to ICU and 2 died (even with remdesivir and serum treatments).

They have started a double blind trial that ought to complete in about a month.

India has approved Itolizumab & Tocilizumab for covid-19 use. Another case of an immune suppressing arthritis drug and an anti malarial. Looks like a pattern to me. But an Italian study found Tocilizumab didn’t benefit. Maybe more folks discovering that real morbidity is under 1% (so given early means your sample is biased to more low symptom folks) or maybe more poorly done trials to make Gilead happy, packed with folks about to die and dosed wrong? Who knows….

I’ll be adding some Ivermectin links in comnents below as I work through my bookmarks.

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About E.M.Smith

A technical managerial sort interested in things from Stonehenge to computer science. My present "hot buttons' are the mythology of Climate Change and ancient metrology; but things change...
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54 Responses to Ivermectin & Doxycycline 98% Cure

  1. Another Ian says:

    This sort of fits here

    “The Push To Discredit HCQ”

    https://realclimatescience.com/2020/08/the-push-to-discredit-hcq/

  2. Another Ian says:

    “One Flu Out Of The Wuhan Nest”

    http://www.smalldeadanimals.com/index.php/2020/08/01/one-flu-out-of-the-wuhan-nest-12/

    Warning on links

    “WIV is Wuhan Institute of Virology. If you poke around in the replies and links, you’ll find a morning’s coffee worth of discussion, including this thread by Alita Chan. As a reminder, Yuri Deigin is the author of this Medium post of April, which if you haven’t read yet I recommend. But be warned, that will take a morning pot’s worth of coffee.”

  3. E.M.Smith says:

    Take your B-12 and Magnesium too…
    https://www.thailandmedical.news/news/supplements-singaporean-researchers-say-that-vitamin-d,-magnesium-and-vitamin-b12-combo-may-reduce-severity-in-older-covid-19-patients

    Links to:

    https://www.medrxiv.org/content/10.1101/2020.06.01.20112334v2

    A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients.

    Chuen Wen Tan, Liam Pock Ho, Shirin Kalimuddin, Benjamin Pei Zhi Cherng, Yii Ean Teh, Siew Yee Thien, Hei Man Wong, Paul Jie Wen Tern, Jason Wai Mun Chay, Chandramouli Nagarajan, Rehena Sultana, Jenny Guek Hong Low, Heng Joo Ng
    doi: https://doi.org/10.1101/2020.06.01.20112334

    This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
    AbstractInfo/HistoryMetrics Preview PDF

    Abstract
    Objective: To determine the clinical outcomes of older COVID-19 patients who received DMB compared to those who did not. We hypothesized that fewer patients administered DMB would require oxygen therapy and/or intensive care support than those who did not. Methodology: Cohort observational study of all consecutive hospitalized COVID-19 patients aged 50 and above in a tertiary academic hospital who received DMB compared to a recent cohort who did not. Patients were administered oral vitamin D3 1000 IU OD, magnesium 150mg OD and vitamin B12 500mcg OD (DMB) upon admission if they did not require oxygen therapy. Primary outcome was deterioration post-DMB administration leading to any form of oxygen therapy and/or intensive care support. Results: Between 15 January and 15 April 2020, 43 consecutive COVID-19 patients aged ≥50 were identified. 17 patients received DMB and 26 patients did not. Baseline demographic characteristics between the two groups was significantly different in age. In univariate analysis, age and hypertension showed significant influence on outcome while DMB retained protective significance after adjusting for age or hypertension separately in multivariate analysis. Fewer DMB patients than controls required initiation of oxygen therapy during their hospitalization (17.6% vs 61.5%, P=0.006). DMB exposure was associated with odds ratios of 0.13 (95% CI: 0.03 − 0.59) and 0.20 (95% CI: 0.04 − 0.93) for oxygen therapy and/or intensive care support on univariate and multivariate analyses respectively. Conclusions: DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supports further larger randomized control trials to ascertain the full benefit of DMB in ameliorating COVID-19 severity.

  4. E.M.Smith says:

    General ivermectin info:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/

    Misc links:

    https://www.worldhealth.net/news/ivermectin-displaying-promising-results/

    Ivermectin Displaying Promising Results
    3 weeks, 4 days ago

    Posted on Jul 07, 2020, 12 p.m.

    A recent study conducted from May 2 to June 5, 2020 at the First Affiliated Hospital Xi’an Jiaotong University involving 116 patients who tested positive for COVID-19 has concluded that concerning treatment outcome, adverse effects, and safety, although both treatments regimes were effective in this study, the combination of Ivermectin with Doxycycline was superior to that of Hydroxychloroquine and Azithromycin therapy for the use in cases of mild to moderate infections.

    The study started with 181 patients, but 42 were excluded because of comorbid conditions that could have impacted recovery time, 14 were unwilling to participate in the study, and 9 failed to participate. The remaining 116 had mild to moderate degrees of illness with normal or near normal chest radiograph and oxygen saturation of over 95%, who were all treated as an outpatient protocol.

    Participants were divided into 2 groups: group A receiving 200 ugm/kg single dose Ivermectin and 100 mg BID of Doxycycline for 10 days; and group B receiving 400 mg of Hydroxychloroquine on the first day followed by 200 mg for 9 days plus 500 mg of Azithromycin for 5 days. Both groups received standard care for any complaints such as fever, headache, cough, they were advised on proper nutrition, hydration, and to self isolate in sanitary conditions. Patients were evaluated every 2 days starting from the fifth day or the second non-symptomatic day from the first day of the treatment intake by PCR study or nasopharyngeal and throat swab.

    Group A Ivermectin/ Doxycycline experienced a 100% recovery rate, with a mean symptomatic recovery of 5.93 days and a negative PCR on 8.93 days.
    55.10% gained symptomatic recovery on day 5 with a mild degree of adverse effect in 31.67% with reports of lethargy in 14 patients, nausea in 11, and occasional vertigo in 7 patients.

    Group B Hydroxychloroquine/Azithromycin experienced a 96.36% recovery rate, with a mean symptomatic recovery of 6.99 days and a negative PCR on 9.33 days
    with some degree of adverse effects with reports of mild types of blurry vision and headaches in 13 patients, increased lethargy and dizziness in 22 patients, occasional palpitation in 10, and nausea and vomiting in 9 patients.

    Looks to me like both work with only a little difference. 3.6%. Then again, I’ll take the 100% please ;-)

    https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2?fbclid=IwAR0N6pVNnHBj2xE0p3r627PMQ6wzGh_1PeN03vO4x7ldFZO44WTcAycdoX4

    ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID19

    Juliana Cepelowicz Rajter, Michael Sherman, Naaz Fatteh, Fabio Vogel, Jamie Sacks, Jean-Jacques Rajter
    doi: https://doi.org/10.1101/2020.06.06.20124461

    This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

    Abstract
    Abstract Importance: No therapy to date has been shown to improve survival for patients infected with SARS-CoV-2. Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in vitro but clinical response has not been previously evaluated. Objective: To determine whether Ivermectin is associated with lower mortality rate in patients hospitalized with COVID-19. Design and Setting: Retrospective cohort study of consecutive patients hospitalized at four Broward Health hospitals in South Florida with confirmed SARS-CoV-2. Enrollment dates were March 15, 2020 through May 11, 2020. Follow up data for all outcomes was May 19, 2020. Participants: 280 patients with confirmed SARS-CoV-2 infection (mean age 59.6 years [standard deviation 17.9], 45.4% female), of whom 173 were treated with ivermectin and 107 were usual care were reviewed. 27 identified patients were not reviewed due to multiple admissions, lack of confirmed COVID results during hospitalization, age less than 18, pregnancy, or incarceration. Exposure: Patients were categorized into two treatment groups based on whether they received at least one dose of ivermectin at any time during the hospitalization. Treatment decisions were at the discretion of the treating physicians. Severe pulmonary involvement at study entry was characterized as need for either FiO2 ≥50%, or noninvasive or invasive mechanical ventilation. Main Outcomes and Measures: The primary outcome was all-cause in-hospital mortality. Secondary outcomes included subgroup mortality in patients with severe pulmonary involvement and extubation rates for patients requiring invasive ventilation. Results: Univariate analysis showed lower mortality in the ivermectin group (25.2% versus 15.0%, OR 0.52, 95% CI 0.29-0.96, P=.03). Mortality was also lower among 75 patients with severe pulmonary disease treated with ivermectin (38.8% vs 80.7%, OR 0.15, CI 0.05-0.47, P=.001), but there was no significant difference in successful extubation rates (36.1% vs 15.4%, OR 3.11 (0.88-11.00), p=.07). After adjustment for between-group differences and mortality risks, the mortality difference remained significant for the entire cohort (OR 0.27, CI 0.09-0.85, p=.03; HR 0.37, CI 0.19-0.71, p=.03). Conclusions and Relevance: Ivermectin was associated with lower mortality during treatment of COVID-19, especially in patients who required higher inspired oxygen or ventilatory support. These findings should be further evaluated with randomized controlled trials.

  5. E.M.Smith says:

    https://medicaldialogues.in/medicine/news/doxycycline-and-ivermectin-combo-may-be-new-effective-covid-19-treatment-65868

    We have got astounding results. Out of 60 COVID-19 patients, all recovered as the combination of the two drugs were applied, said Professor Dr Md Tarek Alam, the head of medicine department at private Bangladesh Medical College Hospital (BMCH). Alam, a reputed clinician in Bangladesh, said a frequently used antiprotozoal medicine called Ivermectin in a single dose with Doxycycline, an antibiotic, yielded virtually the near-miraculous result in curing the patients with COVID-19.

    My team was prescribing the two medicines only for coronavirus patients, most of them initially reporting with respiratory problems with related complaints, later to be tested COVID-19 positive, he said. Bangladesh has so far reported 20,995 coronavirus cases. A total of 314 people have lost their lives in the country due to the disease. Claiming that the efficacy of the drug developed by them was such that patients recovered from the virus within 4 days, he said, adding that there were no side effects of it.

    Another dewormer medication looks promising to U.T. Pharmacy folks:

    https://en.wikipedia.org/wiki/Niclosamide

    https://www.trialsitenews.com/broward-county-doctor-using-ivermectin-off-label-combo-on-covid-19-patients-it-is-working-secures-county-health-protocol-approval/

    Broward County Doctor Using Ivermectin Off-Label Combo on COVID-19 Patients—It is Working & Secures County Health Protocol Approval
    APR 23, 2020 | BROWARD HEALTH MEDICAL CENTER, CORONAVIRUS, COVID-19, IVERMECTIN, OFF-LABEL

    Dr. Jean-Jacques Rajter, a Broward Health Medical Center physician, and his pulmonologist wife are “pioneering” the use of the anti-parasitic drug ivermectin on COVID-19 patients. In fact, thanks to a recent health board decision, they may actually be healing COVID-19 patients with this off-label regimen. TrialSite News introduced the ivermectin Australian laboratory study, and a couple weeks later a small study in France. Now, it is reported that a Florida physician is using the drug off label on patients despite a recent FDA notice. When used in combination at the right time, the results are “remarkable.” His work is getting noticed: The Broward Health Board has approved the off-label protocol!

    TrialSite News breaks down this interesting update from NBC Miami.

    Who is the physician?

    Dr. Jean-Jacques Rajter, Broward Health Medical Center

    What drug is he using off label?

    Ivermectin by itself and in combination with the treatment of hydroxychloroquine, azithromycin and zinc sulfate combination.

    What is his position on this care approach?

    He noted to the local press, “If we get to these people early, and what I mean by that is their oxygen requirements are less than 50%, I’ve had nearly a 100% response rate, they all improve, if they’re on more oxygen than that, then it become a little more varied, some people, they don’t respond anymore because they are too far advanced.”

    What if he waits and doesn’t treat them this way?

    The doctor was quoted, “But if I wait, every day that goes by is another day when lots and lots of people get very sick, go to the ICU, many of them die and that could theoretically even be preventable and that’s why I thought it was so critically important to get this information out there.”

    What combination is he administering to COVID-19 patients?

    Just a few weeks ago he started adding Ivermectin to the hydroxychloroquine, azithromycin and zinc sulfate combination.

    How has it worked?

    A couple weeks after he first tried this combination, he has treated dozens of people with “results so encouraging he called them remarkable.”

    Will he publish the results?

    Yes the doctor is currently in the process of publishing a scientific paper—he is some weeks out from completion.

  6. E.M.Smith says:

    https://blogs.sciencemag.org/pipeline/archives/2020/05/11/whats-up-with-ivermectin

    https://www.trialsitenews.com/category/ivermectin/

    A load of limks in it…

    Ivermectin
    CATEGORY
    Dr. Alam Gets his Randomized Controlled Trial Approved by the Bangladesh Medical Research Council
    JUL 29, 2020 | BANGLADESH MEDICAL COLLEGE, COVID-19, DR. TAREK ALAM, IVERMECTIN, NEWS, POPULAR POSTS

    Dr. Tarek Alam was interviewed by TrialSite News and reported “astounding results” from the administration of Ivermectin and Doxycycline in COVID-19 patients. Dr. Alam acknowledged the need for a randomized controlled trial as he was administering the…

    Top California Gastroenterology Investigator Leads Phase 2 Ivermectin Clinical Trial Targeting COVID-19 Cases
    JUL 22, 2020 | BLOG, COVID-19, DOXYCYCLINE, DR. SABINE HAZAN, IVERMECTIN, NEWS, POPULAR POSTS, PROGENABIOME LLC

    A dynamic research organization in Ventura, California, called Progenabiome, LLC will initiate a Phase 2 clinical trial investigating the efficacy of ivermectin in combination with Doxycycline, much like the successful combination tested by Dr. Tarek Alam from…

    Bangladesh Medical College’s Dr. Tarek Alam’s Ivermectin Working 98% With Between 400-500 Patients & More Research to Come
    JUL 20, 2020 | BANGLADESH MEDICAL COLLEGE, CORONAVIRUS, COVID-19, IVERMECTIN, NEWS, POPULAR POSTS, TAREK ALAM

    Dr. Tarek Alam, a highly respected physician and professor of Medicine at Bangladesh Medical College (BMC), used two economical and easily available drugs to treat patients suffering from COVID-19 with considerable success in not only reducing the patients’ viral…

    Peru’s Universities Now Produce Ivermectin in Collaboration with Regional Health Authorities in a Fight for Survival
    JUL 12, 2020 | BLOG, COVID-19, IVERMECTIN, NEWS, PERU, POPULAR POSTS, SARS-COV-2

    Pedro Ruiz Gallo National University, based in Chiclayo in the north of Peru, has committed to the production of free ivermectin to be distributed throughout this northern coastal region of Peru. Employing specialists and students out of the university’s Faculty of…

    The Italian ‘COVER Trial’ has Regional Hospital & Pharma Research Institute Investigate Ivermectin for Early Stage COVID-19
    JUL 9, 2020 | COVID-19, ITALY, IVERMECTIN, NEWS, POPULAR POSTS, SARS-COV-2, SPAIN

    IRCCS Sacro Cuore Don Calabria Hospital is an accredited Italian provider in the Veneto region that accommodates about 30,000 patients per year, includes 968 beds and employs approximately 1,712. The regional provider has come together with Mario Negri Institute for…

    Qassim University of Saudi Arabia to Launch ‘Worldwide Trends on COVID-19’ Study to include Use of Ivermectin & Hydroxychloroquine
    JUL 8, 2020 | COVID-19, IVERMECTIN, NEWS, OBSERVATIONAL STUDY, POPULAR POSTS, QASSIM UNIVERSITY

    Saudi Arabia’s Qassim University observed with great importance the outburst of clinical research, both interventional and observational, with the onset of the pandemic. The university has taken a keen interest in better understanding these studies can help in…

    University of Baghdad Pilot Clinical Trial: Ivermectin plus Hydroxychloroquine & Azithromycin Superior to No Ivermectin
    JUL 8, 2020 | BLOG, IVERMECTIN, NEWS, POPULAR POSTS, POSITIVE RESULTS, UNIVERSITY OF BAGHDAD

    The TrialSite Network eagerly awaited a pilot clinical trial investigating the safety and efficacy of Ivermectin sponsored by the University of Baghdad in Iraq. Led by Professor Faiq Gorial, this study target 100 patients in a Phase 1 clinical trial investigating the…

    13 Promising COVID Treatments Emerging From Israel Includes Ivermectin
    JUL 7, 2020 | COVID-19, IVERMECTIN, NEWS, POPULAR POSTS

    Scientists across the globe are working on vaccines to prevent Covid-19 infection. But in the meanwhile, and even after initial vaccines are approved, there is an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus….

    Delhi’s COVID-19 Provider Lok Nayak Hospital Cuts Favipiravir & Adds Ivermectin & Remdesivir for COVID-19 Patients
    JUL 4, 2020 | CORONAVIRUS, COVID-19, FAVIPIRAVIR, INDIA, IVERMECTIN, NEWS, POPULAR POSTS

    Lok Nayak Hospital is the national capital’s first COVID-19 only facility. Although Favipiravir was recently embraced in India by Glenmark Pharmaceuticals in the form of Fabiflu, this Delhi hospital has discontinued the use of the drug for COVID-19 patients. The…

    Prominent Brazilian University Embarks on Phase 2 Ivermectin Clinical Trial
    JUL 3, 2020 | BRAZIL, COVID-19, IVERMECTIN, NEWS, POPULAR POSTS, SARS-COV-2, THE FEDERAL UNIVERSITY OF SAO CARLOS

    The Federal University of Sao Carlos, (UFSCar) a public research university located in Sao Carlos, in the state of Sao Paulo Brazil was established in 1968 and supports the education of over 15,000 undergraduates and about 4,700 graduate students. Ranked among the top…

    President of Dominican Republic’s Largest Private Health Group Discusses the Success of Ivermectin as a Treatment for Early Stage COVID-19
    JUN 30, 2020 | BLOG, COVID-19, DOMINICAN REPUBLIC, IVERMECTIN, NEWS, OFF-LABEL, POPULAR POSTS

    The Rescue Group (Grupo Rescue) is a leading national private health network in the Caribbean nation of Dominican Republic. The Rescue Group operates three hospitals, including Punta Cana Medical Center, Bournigal Medical Center (Puerto Plata) and Canela Clinic (La…

    Ivermectin Study Reveals Fantastic Results: 100% of 60 Patients Better in an Average of Just Under 6 Days
    JUN 28, 2020 | COVID-19, IVERMECTIN, NEWS, POPULAR POSTS, POSITIVE RESULTS, UPAZILA HEALTH & FAMILY PLANNING OFFICER’S (UHFPO) OFFICE

    Recently, TrialSite News reported on a study sponsored in Bangladesh by Upazila Health & Family Planning Officer’s (UHFPO) Office, Chakoria, Cox’ Bazar and Abu Taiub Mohammad Mohiuddin Chowdhury, First Affiliated Hospital Xi’an Jiaotong University. The…

    WHO & Pan American Health Organization Position on Ivermectin Use & COVID-19: Produce Evidence via RCT
    JUN 25, 2020 | COVID-19, IVERMECTIN, NEWS, PAN AMERICAN HEALTH ORGANIZATION, WORLD HEALTH ORGANIZATION

    Recently, the Pan American Health Organization (PAHO) and the WHO (World Health Organization) came together to respond to the growing use of Ivermectin around the world (especially in South America) to treat COVID-19. Although the “Monash” study demonstrated…

    National University Singapore Launches Large COVID-19 Prophylaxis Study Targeting Ivermectin & HCQ
    JUN 24, 2020 | COVID-19, HYDROXYCHLOROQUINE, IVERMECTIN, LEADING SITES, NEWS, SINGAPORE, SITE SUCCESS, SITE WATCH

    The National University of Singapore serves the island nation as a tertiary hospital, clinical training center, and research center for medical and dental faculties. With 1,160 beds serving more than 670,000 outpatients and 49,000 inpatients, NUS is ranked first in…

    Thailand’s Largest Hospital to Initiates Ivermectin Clinical Trial in COVID-19 Patients
    JUN 21, 2020 | COVID-19, IVERMECTIN, MAHIDOL UNIVERSITY, NEWS, SARS-COV-2, SIRIRAJ HOSPITAL, THAILAND

    The oldest and largest hospital in Thailand, Bangkok-based Siriraj Hospital with Mahidol University, makes a move to test Ivermectin in COVID-19 patients. Founded in 1888 by King Chulalongkorn after a cholera outbreak, the hospital today has 2,221 beds. The hospital…

    100-Year-Old Discharged from Mumbai’s Rajawadi Hospital after Successful Ivermectin Treatment
    JUN 18, 2020 | COVID-19, IVERMECTIN

    A 100 year old Indian man survived COVID-19 thanks first and foremost to his own strong will, dedicated health care team and also the use of Ivermectin. Ramlal Mali was recently discharged from Rajawadi Hospital recently after nearly a month in the hospital. He was…

    In Pursuit of Real-World Ivermectin Stories: Tales from Pathanamthitta
    JUN 17, 2020 | COVID-19, INDIA, IVERMECTIN, REAL WORLD EVIDENCE, REAL-WORLD DATA

    A request came from someone in the TrialSite Network out of India to look into a Times of India story reporting that a Pathanamthitta, Kerala-based health team has successfully treated six severe to critical COVID-19 patients with Ivermectin. The patients, including…

    MedinCell Announces Great Success with Capital Raise of 15.6M€ & Use of Proceeds Includes Ivermectin Prophylactic for COVID-19
    JUN 16, 2020 | COVID-19, INVESTOR WATCH, IVERMECTIN, MEDINCELL, NEWS

    France-based Medincell recently experienced strong investor demand leading to a capital raise of 15.6m€ ($17.6m). The funding will be deployed for research and development (R&D) activities, including the expansion and advancement of its long-acting injectable…

    Top Israeli Scientist & Physician Embraces Ivermectin for Clinical Trial & Raises Possibility the Drug Could Beat COVID-19
    JUN 15, 2020 | COVID-19, ISRAEL, IVERMECTIN, SHEBA MEDICAL CENTER

    Professor Eli Schwartz, founder of the Center for Travel Medicine and Tropical Disease at Sheba Medical Center, Tel Hashomer, launched a clinical trial involving ivermectin, the broad-spectrum antiparasitic therapy that absolutely destroyed the novel coronavirus…

    How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru
    JUN 12, 2020 | BLOG, COVID-19, HYDROXYCHLOROQUINE, IVERMECTIN, NEWS, PERU, SARS-COV-2

    Perhaps Peru is the epicenter of the movement for off-label use of Ivermectin to treat COVID-19 patients. The doctors there swear by it. In fact, some of them curse the government for not embracing the anti-parasite drug sooner as they believe more lives could have…

  7. E.M.Smith says:

    https://www.jpost.com/health-science/israeli-researcher-anti-parasitic-drug-could-cure-coronavirus-631526

    Israeli researcher: Antiparasitic drug could ‘cure’ coronavirus
    Prof. Eli Schwartz launched a clinical trial of the drug Ivermectin, a broad-spectrum antiparasitic agent that has also been shown to fight viruses.
    By MAAYAN JAFFE-HOFFMAN JUNE 15, 2020 15:05

    Prof. Eli Schwartz, founder of the Center for Travel Medicine and Tropical Disease at Sheba Medical Center, Tel Hashomer, recently launched a clinical trial of the drug Ivermectin, a broad-spectrum antiparasitic agent that has also been shown to fight viruses. He believes the drug could help “cure” COVID-19.
    “At the onset of this virus, everyone was talking about the anti-malaria drug,” he said, referring to hydroxychloroquine, which was first touted by US President Donald Trump, but has since been linked to increased risk of death in coronavirus patients, among other health risks.
    “We decided to look more widely for other medications and considered a few drugs that might have antiviral activity,” he said; Ivermectin was selected.

    https://clinicaltrials.gov/ct2/show/NCT04422561

    Looking at prophylactic use in exposed family& contacts:

    Prophylactic Ivermectin in COVID-19 Contacts
    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.

    ClinicalTrials.gov Identifier: NCT04422561
    Recruitment Status : Recruiting
    First Posted : June 9, 2020
    Last Update Posted : July 14, 2020
    See Contacts and Locations
    Sponsor:
    Zagazig University
    Information provided by (Responsible Party):
    Waheed Shouman, Zagazig University

    Brief Summary:
    asymptomatic family close contact of confirmed COVID -19 patient will receive prophylactic ivermectin and will be followed up for 14 days for any symptoms & diagnosis of COVID -19

    https://www.newsmax.com/us/ivermectin-drug-virus/2020/05/22/id/968688/

    Interesting that I saved the link a while ago, but it shows todays date. Updated? But an older date in the article propet, so maybe jyst mssthead date?

    Saturday August 01, 2020

    Breakthrough Drug: Ivermectin Shows ‘Astounding’ Results Against Coronavirus

    By David A. Patten | Friday, 22 May 2020 11:16 PM

    Reports Friday from multiple trials in the United States and abroad indicate a drug already approved by the FDA to treat parasitic infections is showing “astounding” results, and could represent a breakthrough in efforts to vanquishing the SARS-CoV-2 virus at the heart of the global pandemic.

    Doctors have administered the drug ivermectin in several simultaneous trials in several countries sometimes in combination with other common medications.

    Physicians who participated in the study report that patients’ viral loads began declining almost immediately after they began administering ivermectin
    , a widely available prescription drug approved to combat parasites, scabies and head lice.

    It has not been approved for COVID-19 patients, but doctors familiar with clinical trials described patients’ results as dramatic.

    Emergency medical physician Dr. Peter H. Hibberd, M.D., of Palm Beach County, Florida, told Newsmax Friday evening in an exclusive interview that he’s optimistic the drug will prove to be an important therapeutic advance, although he expects more trials will be needed before it wins FDA approval for use as a COVID-19 medication.

    He noted it has impressed doctors in clinical trials on multiple continents.

    “There’s a common denominator here,” said Hibberd. “This drug is salvaging people from their death bed.”

    In some cases, doctors reported just one dose of ivermectin markedly improved a patient’s condition. U. S. patients received a single oral dose, and some of them received a booster dose seven days later. The FDA-approved dose for parasitic infections was used.

    [..,]

    On Thursday, a team of U.S. doctors led by Dr. Jean-Jacques Rajter at the Broward Health Medical Center in Fort Lauderdale, Florida, submitted findings to an institutional review board. According to a medical source familiar with the study, some 250 coronavirus patients were involved in the Broward trial. The results were dramatic, with “statistically significant improvement in mortality,” according to the source.

    The blood oxygen level of the first patient treated in early April was 70%, and dropped to just 50% within hours. After receiving the invermectin, the patient stabilized within 24 hours and was discharged from the hospital in one week.

    […]

    In a separate trial on the other side of the globe, a team of doctors in Bangladesh reported Friday that they administered a combination of ivermectin and doxycycline, a common antibiotic, to 60 coronavirus patients there.

    That team reported that within 72 hours after receiving the drug, their patients tested negative for the virus, and by the fourth day, they had recovered. Dr Tarek Alam, a senior doctor for the Bangladesh Medical College Hospital, told India’s ZeeNews that the results were “astounding” and said all patients “experienced full recoveries.”

    […]

    Hibberd said the ivermectin trials indicate it is an “effective therapy” that would provide a bridge to a vaccine and would potentially reduce the downside risk of catching the virus.

    “It would mean we could go to work and not worry,” he said of the prospect of having an effective therapeutic medication. “You catch it, we treat you and we move on as a country.”

    https://www.clinicaltrials.gov/ct2/show/NCT04373824

    Sponsor:
    Max Healthcare Insititute Limited
    Information provided by (Responsible Party):
    Max Healthcare Insititute Limited

    Brief Summary:
    At present, there are no specific treatments for COVID-19. WHO recommends four treatments for COVID 19 with drugs i.eRemdesivir, Lopinavir/ ritonavir, Lopinavir/ ritonavir with interferon beta -1a, and chloroquine or hydroxychloroquine. Currently, there are several ongoing clinical trials evaluating potential treatments. Recently, LeonCaly reported that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARSCoV-2 able to effect about 5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrant further investigation for possible benefits in humans. The study rationale is to understand the effect of the drug on eradication of virus.

    Detailed Description:
    This study aims to confirm the antivirus effectiveness of Ivermectin on coronavirus i.e COVID 19 then to explore its potential use in the combating to the COVID 19 pandemics.

    Enrollment of subject into the trial shall only occur after providing written permission to voluntarily participate into the study by signing and dating the informed consent form before starting any trial related treatment. 50 cases of COVID-19 will be enrolled into the trial. The trial shall be divided into two groups. First group with 25 confirmed cases of COVID 19 shall be treated with Ivermectin 200 to 400 mcg per kg body weight on day 1 and day 2 along with standard treatment of the hospital protocol. The second group with 25 confirmed cases of COVID 19 shall be treated with standard treatment as per hospital protocol for COVID 19. Subjects in both the arms shall be followed up for recovery of death with regular monitoring as per below schedule.
    […]

    https://clinicaltrials.gov/ct2/show/NCT04438850

    Sponsor:
    IRCCS Sacro Cuore Don Calabria di Negrar
    Collaborator:
    Istituto Di Ricerche Farmacologiche Mario Negri
    Information provided by (Responsible Party):
    IRCCS Sacro Cuore Don Calabria di Negrar

    Brief Summary:
    Prospective, multi-centre, randomized, double-blind trial to assess efficacy and safety of ivermectin for the treatment of initial infection with SARS-CoV2 infection.

    Study arms: A) placebo B) ivermectin 600 μg/kg daily for 5 consecutive days (I_600) + placebo. C) ivermectin 1200 μg/kg daily at empty stomach with water for 5 consecutive days (I_1200). Patients will be randomized at emergency room of hospitals as well as at outpatient ambulatory care as well as at home, according to routine procedures of recruiting centres.

    In arm A and B, the number of placebo tablets to be administered will be calculated by the study dedicated pharmacist considering the number of tablets that should be taken in case a patient with the same weight is assigned to arm C.

    Detailed Description:
    This study aims to confirm the antivirus effectiveness of Ivermectin on coronavirus i.e COVID 19 then to explore its potential use in the combating to the COVID 19 pandemics.

    Enrollment of subject into the trial shall only occur after providing written permission to voluntarily participate into the study by signing and dating the informed consent form before starting any trial related treatment. 50 cases of COVID-19 will be enrolled into the trial. The trial shall be divided into two groups. First group with 25 confirmed cases of COVID 19 shall be treated with Ivermectin 200 to 400 mcg per kg body weight on day 1 and day 2 along with standard treatment of the hospital protocol. The second group with 25 confirmed cases of COVID 19 shall be treated with standard treatment as per hospital protocol for COVID 19. Subjects in both the arms shall be followed up for recovery of death with regular monitoring as per below schedule.

  8. E.M.Smith says:

    Oh, and the in vitro test that was the start of it all:

    https://www.sciencedirect.com/science/article/pii/S0166354220302011

    “The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro”

    I think that’s all, but if I run into more I’ll put it here.

  9. Nancy & John Hultquist says:

    The COSTCO multi-tablet has Zink, B12, and Vit-D. Not a lot of the D. I add a D3 pill (2000 units). We don’t eat much of those things high in D, and get very little exposure to sunlight.
    Vitamin D deficiency in US adults is a serious issue, much ignored.

    My wife is loaded up on meds because of heart issues. If either of us show signs of virus/flu there will be quick and serious discussion with the pros. Our first contact is a young lady with 6+ years of being a Physician Assistant under several different doctors. I guess there is an MD at the clinic, but it has been 3 years since I’ve seen one and this one has been in-house less than 2 years.

    We have experience with Ivermectin as a horse wormer. Works well for them.
    _ _ _ _
    The U. S. medical folks were ill prepared for this virus, or similar.
    Too bad all the money was shunted off to CO2 related things, such as wind mills, solar-pv, and mirrors. Not to mention pallets of cash to Iran, and millions to the UN’s green slush fund.
    It is enough to make a person angry.

  10. E.M.Smith says:

    I ran into Ivermectin via my rabbits and trying to fix an intracellular parasite they get. Did my deep dive on it and then, later, used the drench on myself when I had a non-resolving rash that I figured was a tropical bug; but my MD said it couldn’t be since I’d not been to the tropics…. and didn’t care that my neighbor had been, had a rash on his hand, and we’d done the handshake thing…

    BTW, the rash left fairly quickly after Ivermectin ( after months of getting worse and spreading. MD had just declared it self induced via scratching and handed me salve…. which did nothing).

    Ivermectin appears to interupt some primative pathway essential to primative life forms, but where people & mammals have newer redundant pathways we can use. I had exactly zero side effects from a “sheep dose” rubbed into the skin. (about a cap full of drench. It just soaks in in a minute or two.)

    IMHO, most US doctors have little skill with either tropical diseases or parasites, and if you get off page from “the usual” they can’t imagine hoof beats ARE sometimes a zebra, not a horse. Even less educated on history of medicine and just how many plants & fungi are medicinal, and pretty clueless about actual nutrition issues. (Ask them about carbs and heart disease, or vit-C and arterial plaque, or omega 3 vs 6 oils and health… you have high probability of getting the USA Food Pyramid that makes folks sick, the high carb diet that causes diabetes, and the low fat low cholesterol diet instead of keto plus vit-C that eliminates problems.)

    Oh Well. When you find one with clue, it is great, so hang on to them when you find one.

    For me, personally, I’d much rather use an MD than self treat. But when it becomes clear my 50 hours of a deep data dive on whatever I’ve got exceeds their 4 hours in a class 12 years ago, AND they are unwiling to get updated, well, I’m willing to DIY.

    So I spent the money to get an 8 oz. bottle of drench to refresh my stock. I’d used the last dose of the old bunny bottle some weeks back when I had that “cold starting, nose feels inflamed, sparkle feeling in nerves all over, feel off” and just didn’t want to deal with even a regular cold in a pandemic. Yes, it ended that in one day and a bit. Again with zero side effects. One bottle is about 20 treatments so about $1.50 per. I’m willing to have that wasted sitting on the shelf just for the EOTWAWKI inventory of emergency treatments.

    IF I get Wuhan Covid, I’ll start with the M.D., but if it is just all “no treatment approved, come back when you need a ventilator” (as it has been…), well, OK, I have options. Gin & tonic for the quinine, doxycycline is easy to get, up the nutrients, daily mushroom omlette & mushroom sautee topper on lamb chops (lamb high in omega-3 fats, short chain fats, and other good things, mushrooms medicinal and antiviral), and, if necessary, a bit of ivermectin drench.

    BTW, the medicinal action of mushrooms is fascinating. Any will do, but some are exceptional. IIRC, shiitaki, lions mane, and oyster mushrooms in particular (without getting into the non-commercial exotics like agaricon, cordyceps).

    https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2629-y

    Results
    We found that the HAEs and ASEs of L. rhinocerotis, P. giganteus, H. erinaceus and S. commune were the least toxic to Vero cells and showed very prominent anti-DENV2 activity. The 50% inhibitory concentration (IC50) values of the ASEs ranged between 399.2–637.9 μg/ml, while for the HAEs the range was 312.9–680.6 μg/ml during simultaneous treatment. Significant anti-dengue activity was also detected in the penetration assay of ASEs (IC50: 226.3–315.4 μg/ml) and HAEs (IC50: 943.1–2080.2 μg/ml). Similarly, we observed a marked reduction in the expression levels of the ENV and NS5 genes in the simultaneous and penetration assays of the ASEs and HAEs. Time-of-addition experiments showed that the highest percent of anti-DENV2 activity was observed when the mushroom extracts were added immediately after virus adsorption. None of the extracts exhibited virucidal effect. Chemical composition analysis showed that the major components in the mushroom HAEs and ASEs were glucan (beta D-glucan) and proteins, however, there was no significant correlation between the anti-dengue activity and the concentration of glucans and proteins.
    […]

    Culinary and medicinal mushrooms have great prospects in the drug and nutraceutical industries. They possess a wide range of pharmacological properties, including antimicrobial, antiviral, antitumour, anti-inflammatory, immunomodulatory, hypoglycaemic and hepatoprotective properties, and thus can be considered a functional food. Mushroom antiviral activities have been reported towards human immunodeficiency virus (HIV) using lectin isolated from Hericium erinaceus [4] and laccase isolated from Clitocybe maxima [5]. An acidic protein bound polysaccharide isolated from Ganoderma lucidium [6] and a protein from Grifola frondosa [7] inhibited the replication of the herpes simplex virus (HSV). Influenza viruses have been inhibited by ganomycins A and B from Ganoderma pfeifferi [8] and polysaccharides isolated from Agaricus brasiliensis showed antiviral activity against polioviruses [9].

    In this study, five culinary and medicinal mushrooms that are commercially grown in Malaysia, Lignosus rhinocerotis (Cooke) Ryvarden, Pleurotus giganteus (Berk) Karunarathna & K.D.Hyde, Hericium erinaceus (Bull) Persoon, Schizophyllum commune (Fr.) and Ganoderma lucidium (Curtis) P. Karst were selected for in-vitro screening for their anti-dengue serotype 2 (DENV-2) activity

    Besides, butter sauteed mushrooms taste really good!

    So work them into your meal plans on a regular basis Since different compounds are active in different mushrooms, use several kinds. Asian markets have interesting ones and Whole Foods has Lion’s Mane. If nothing else, you get interesting tasty meals and added nutrients.

  11. A C Osborn says:

    EM, that is a great roundup of data.
    I suggested B12 some time back because my son is B12 deficient which adversely affects his Fibromyalgia.
    The evidence is building that the various western world health services have been allowing people to die unnecessarily due to either dogma or for more nefarious reasons like Cash.

  12. E.M.Smith says:

    @A.C.Osborn:

    Yup. I remember your call for B-12. I’ve been taking it since.

    I think it telling that the big leaps are comming from doctors in poor lands. They must quickly find a way with what they have. USA and EU doctors seem frozen by legal liability, tied up in government regulatory red tape, and fixated on formal research with publication taking months to years. Then there is all that pharma cash…

    They seem to have forgotten that rapid trials, observation, experience, and adoption had worked well enough for centuries. Yes, with higher error rates. But sometimes rapid matters more. When time matters, rapid prototyping and iteration beats pedantry.

  13. A C Osborn says:

    EM, unfortunately for me I am allergic to mushrooms, even mushroom sauce has me throwing up in an hour or two.

  14. E.M.Smith says:

    Oh, and just for completion:

    Doxycycline has direct antiviral activity by itself.

    https://pubmed.ncbi.nlm.nih.gov/26459887/

    Abstract
    Doxycycline (Dox) is a tetracycline derivative with broad-spectrum antimicrobial activities that is used as an effector substance in inducible gene-expression systems. We investigated the antiviral activity of Dox against vesicular stomatitis virus (VSV) infection in cultured H1299 cells. Dox at concentrations of 1.0-2.0 μg ml(-1) significantly inhibited VSV replication and the VSV-induced cytopathic effect in dose-dependent manners, suggesting that Dox may have broader activity in inhibiting viral replication, in addition to its well-defined bacteriostatic activity. Dox exerted its antiviral effect at the early-mid stage of VSV infection, suggesting that it did not interfere with VSV infectivity, adsorption, or entry into target cells. These results indicate that Dox can inhibit VSV infection and may therefore have potential applications for the treatment of viral infections.

    So be prepared to score doxy from that kid with bad acne ;-)

    Or at least to show the article to your M.D. (whom often, here, prescribe doxycycline for everything or just to shut you up…)

  15. E.M.Smith says:

    @A C Osborn:

    I’d be surprised if it is all mushrooms as there are many very divergent species.

    OTOH, I can understand the desire to avoid searching the space and potentially a dozen “rejections via ejections”.

  16. nessimmersion says:

    With reference to your comment about Doctors in poorer lands vs 1st world.

    https://c19study.com/

    Also noticed Singapore is referenced more than once, Karl Denniger at the market ticker has been banging on about them reducing their Nosocomial infection rate to zero in March and the rest of the world ignoring as “Not Invented Here Syndrome”

    https://market-ticker.org/akcs-www?post=239747

  17. H.R. says:

    By chance, something good has come out of my diabetes. I have been taking Super-B complex twice a day for a few years. My podiatrist prescribed large doses of all of the B vitamins to prevent degradation of the myelin sheath, which is the cause of a lot of bad foot pain in diabetics.

    The B vitamins don’t reverse any damage, but so far, they are the only known treatment to prevent further damage.

    So I’m getting lots of B12 as well as all the other Bs.

    (The Doc said, “Here’s and Rx for a super B-complex. If your insurance won’t cover it, just go find the strongest over the counter B-complex vitamin you can and take a couple of those per day.”

    The Rx was going to be $100+ per month – screw that – so I get a high potency Super B-complex from Costco, dirt cheap.)

  18. p.g.sharrow says:

    Not sure if it has anything to do with these other viral treatments but, I have shingles outbreak from time to time on my feet. At the first sign of blisters I take 1-1000mg Lysine and by morning they are gone for a week or two. Lysine inhibits viral replication.

  19. cdquarles says:

    Our host said: “IMHO, most US doctors have little skill with either tropical diseases or parasites, and if you get off page from “the usual” they can’t imagine hoof beats ARE sometimes a zebra, not a horse. Even less educated on history of medicine and just how many plants & fungi are medicinal, and pretty clueless about actual nutrition issues. (Ask them about carbs and heart disease, or vit-C and arterial plaque, or omega 3 vs 6 oils and health… you have high probability of getting the USA Food Pyramid that makes folks sick, the high carb diet that causes diabetes, and the low fat low cholesterol diet instead of keto plus vit-C that eliminates problems.)”, and this is true, though they should be willing (and don’t the licensing bureaus demand keeping up via continuing education) to ask questions and seek outside consultation and/or do their own research (which is easier than ever today).

  20. pyromancer76 says:

    Thanks, EM, and commenters for all successful new therapies, supplements, and foods.

    When I look for the success, or not, of HCQ in every study, I always look for its use only/mainly at the beginning. Also it must be given with bio-available zinc, which is the virus killer, if it can get access to our cells. For that it needs an ionophore – HCQ’s job. HCQ also “fills” and protects the other organs, as I understand it. Watched a lot of DrBeen and EVMS Dr. Marek’s updated protocols.

    EM, I just mentioned your studies on early cultures/civilizations and their rise and fall often associated with climate cycles – at WUWT.

    https://wattsupwiththat.com/2020/08/01/younger-dryas-impact-hypothesis-takes-another-hit/

  21. E.M.Smith says:

    @P.G.:

    Interesting… didn’t know about that one. So have your cheeseburger lunch and steak dinner…. and chew on some olive leaves ;-)

    https://doctorsnutrition.com/the-natural-antiviral-effects-of-lysine-and-olive-leaf-extract/

    Natural ways to fight viruses
    Both L-lysine and Olive Leaf are very effective at fighting viruses.

    Extracts from olive leaves have been shown to treat infection caused by a large number of viruses as well as bacteria, parasitic protozoans, and fungi. A phytochemical in olive leaf, call oleuropein, is able to stop viruses in their tracks. Oleuropein neutralizes the enzymes that are important for the virus to replicate itself and spread. Oleuropein also has the ability to interfere with the critical amino acid production essential for viruses.

    L-lysine, an essential amino acid, may be the most effective treatment against the herpes virus. Lysine is both preventative as well as able to treat active infections. When combined with zinc, lysine has been shown to eliminate nearly all herpes virus symptoms within six days.

    In addition to fighting viruses, L-lysine has many other benefits.

    L-lysine helps fight cancer.
    It reduces anxiety.
    It helps the body absorb calcium to prevent osteoarthritis.
    It benefits people with diabetes by preventing the production of advanced glycation end products which can lead to infection.
    It supports a healthy gut by preventing leaky gut syndrome and also suppresses inflammation that leads to pancreatitis.

    https://www.healthline.com/health/lysine-foods#lysine-in-meat

    Plant-based foods rich in lysine
    Although animal products are the most well-known sources of lysine, you can get plenty of it from vegan or vegetarian sources as well.
    [..,]
    Vegetables and fruit
    avocados
    dried apricots and mangoes
    beets
    leeks
    tomatoes
    pears
    green and red peppers
    potatoes
    Legumes
    soy-based products like:
    tempeh
    tofu
    soybeans
    soy milk
    beans, including:
    kidney beans
    navy beans
    black beans
    chickpeas and hummus
    lentils
    edamame
    Nuts, seeds, and grains
    pumpkin seeds
    pistachios
    cashews
    macadamia nuts
    Grains aren’t usually rich in lysine but some notable exceptions — that just happen to be great for you — are:

    quinoa
    amaranth
    buckwheat
    seitan

    Meat and dairy products rich in lysine
    Animal products like fish and eggs are rich in lysine. Other animal-based sources of lysine include:

    Dairy-based products
    yogurt
    cheese
    butter
    milk
    Seafood
    oysters
    shrimp
    snails
    Meats
    beef
    pork
    chicken
    If you want to consume additional lysine for the treatment of the herpes simplex virus, keep your arginine consumption low. Diets high in lysine and low in arginine can be used to help prevent and treat herpes.

    One example of a dairy product that may meet that need is grated, low-fat parmesan cheese. This cheese ranks high in lysine and lower in arginine with:

    2.2 grams of lysine per 100 grams of cheese
    1.5 grams of arginine
    Roasted beef and steaks are also high in lysine content without being high in arginine. A top round steak (85 grams or 3 ounces) with bones and fat trimmed gives you:

    3 grams of lysine
    just a little over 2 grams of arginine

    So chilli beans ought to be particularly good, noodles and bread not so much….

    Cheese burger and fries good, skip the rice or couscous.

  22. E.M.Smith says:

    Thìngs to avoid:

    https://www.coldsorescured.com/foods-high-in-arginine/

    Why Do High Arginine Foods Cause Cold Sore Breakouts?
    Medically reviewed by Emina Ribic (MD) on August 22, 2018. Written by Linda White (MD).
    Understanding the connection between cold sores and amino acids is very important. Arginine is a part of the diet that experts believe can activate herpes simplex one. A few days later, this results in the appearance of ugly skin lesions that cause so much pain and embarrassment.
    […]
    Can Arginine Reduce the Effectiveness of Medications?
    It can reduce the effectiveness of cold sore medications. Promoting viral growth and replication, arginine is the ultimate anti-medication.

    While it will not render all medications useless, you may find that outbreaks occur much sooner and more often, even if you apply/take medication.

    In the same way that medication can only treat a cut as long as the wound remains closed, the same logic can be applied to arginine and medications.

    The only way to ensure effectiveness is to reduce your arginine intake drastically. This typically requires a change in dietary regimen.

    Which Diet Plans Contain the Most Arginine?
    Certain foods contain more arginine than others. Obviously, the foods that contain the most arginine should be avoided if you want to decrease the frequency of cold sore outbreaks.

    Let’s take a closer look at five of the harshest foods:

    1. Nuts are rich in arginine and should not be consumed if you are susceptible to cold sores. Although healthy, peanuts, hazelnuts, and walnuts will fuel development and replicate existing viral cells.

    2. Chocolate is packed with arginine. While dark chocolate is considered to be less of a problem than milk chocolate, it should still be avoided.

    3. Wheat isn’t a good option. It is found in many common foods (bread, pasta, and a wide assortment of baked goods). Wheat consumption can be hard to avoid unless you’re really on top of your dietary plan.

    4. Pumpkin seeds, similar to nuts, are really high in arginine. While not common in main course dishes, pumpkin seeds are often consumed as a healthy snack. If pumpkin seeds are a regular staple of your diet, it is vital to make the appropriate dietary modifications.

    5. Stay away from squash (the vegetable) if you want your cold sores to remain dormant. Whether eaten individually or in a casserole, it’s argued that squash should typically be avoided.

    Obviously, this is just a small selection of foods that you ‘may’ wish to avoid. The vegan diet can be bad for cold sores. Since most selections are rich in arginine, it is vital to make some strategic dietary adjustments.
    […]
    What’s the Connection between Lysine and Arginine?
    While arginine is can be a cold sore trigger, lysine is an amino acid that can help you.

    Found in various food selections such as red meat, poultry, and fish, lysine is also available in supplement form or can be applied to the skin topically as a lysine cream or lysine lip balm.

    By most accounts, lysine’s primary benefit is that it’s a cold sore remedy and/or preventative treatment. Lysine is believed to slow the growth and replication of viral cells.

    The objective is to consume more lysine and less arginine. Many people who get cold sores adhere to a strict lysine-to-arginine ratio.

    So now I’m wondering if this might also enter into other virus replication and differences in national Chinese Wuhan Covid outcomes.

  23. E.M.Smith says:

    We have bingo!

    https://www.researchgate.net/publication/312115736_D_L-lysine_acetylsalicylate_glycine_Impairs_Coronavirus_Replication

    D, L-lysine acetylsalicylate + glycine Impairs Coronavirus Replication
    Article (PDF Available) in Journal of Antivirals and Antiretrovirals 8(4) · December 2016 with 31,002 Reads 
    DOI: 10.4172/jaa.1000151

    Abstract
    Coronaviruses (CoV) belong to the large family Coronaviridae within the order of Nidovirales. Among them, several human pathogenic strains (HCoV) are known to mainly cause respiratory diseases. While most strains contribute to common cold-like illnesses others lead to severe infections. Most prominent representatives are SARS-CoV and MERS-CoV, which can lead to fatal infections with around 10% and 39% mortality, respectively. This resulted in 8098 casualties in the 2002/2003 SARS-CoV outbreak and in 1806 documented human infections (September 2016) during the recent ongoing MERS-CoV outbreak in Saudi Arabia. Currently patients receive treatment focusing on the symptoms connected to the disease rather than addressing the virus as the cause. Therefore, additional treatment options are urgently needed which would ideally be widely available and show a broad affectivity against different human CoVs. Here we show that D, L-lysine acetylsalicylate + glycine sold as ” Asprin i.v. 500mg® ” (LASAG), which is an approved drug inter alia in the treatment of acute pain, migraine and fever, impairs propagation of different CoV including the highly-pathogenic MERS-CoV in vitro. We demonstrate that the LASAG-dependent impact on virus-induced NF-κB activity coincides with (i) reduced viral titres, (ii) decreased viral protein accumulation and viral RNA synthesis and (iii) impaired formation of viral replication transcription complexes.

  24. Tonyb says:

    This is where the hysteria has got us, in what must be the most worrying and authoritarian statement ever issued in peace time by any democratically elected western leader

    https://www.dhhs.vic.gov.au/updates/coronavirus-covid-19/premiers-statement-changes-melbournes-restrictions

    Tonyb

  25. philjourdan says:

    What is missing?

    The US being involved in any of this. Thanks to the fake news media and democrats. Such a sad day when 2 groups work for the deaths of Americans instead of saving lives.

  26. beththeserf says:

    A serf in lock-down responding to Tony’s comment onnew restrictions in Oz State of Victoriastan, Agenda 21 in action by our leftist premier. 8pm to 5.am curfew, 1 hour day- light hours to exercise or go to shops Mr Soros plans working nicely.

    Came across this, a handy chart. tho’ not complete, leaves out many shady interconnections like Alliance for Global Justice, one of Soros’ top 7 grantees, funding Rise-Up and Anti-Fa.
    Hey big spender! https://pbs.twimg.com/media/Ed7nom6XYAATbZd?format=jpg&name=900x

  27. YMMV says:

    E.M.Smiths: “We have bingo!”

    I am surprised that there were no ripples in the media. There was another study of Aspirin 100 mg. No results posted yet.
    https://clinicaltrials.gov/ct2/show/NCT04365309

  28. E.M.Smith says:

    @YMMV:

    So aspirin alone helps. Lysine alone helps. Lysine and aspirin in that combo medication with glycine helps (LASAG which when read letter by letter has me thinking Los Angeles Screen Actors Guild :- )

    So the necessary conclusion is burger & fries or steak & baked potato with aspirin ought to help too (mushroom topper optional).

  29. jim2 says:

    The covid therapeutic response by the US is symptomatic of the top-down control espoused by Dimowits everywhere. Our founders saw this flaw hundreds of years ago. We are more technologically advanced, but not one whit smarter. (Political whit mechanics?)

  30. p.g.sharrow says:

    Hey Jim2; Even more scary, half of all people have below average intelligence, And they vote!

  31. jim2 says:

    PGS – Now there’s a study I would like to see. Find out how the lower half votes. I’m not sure it’s a slam dunk one way or another, although “free stuff here” is pretty easy to understand.

  32. philjourdan says:

    @Jim2 – sadly PGS statement is a truism. Which means it is a mathematical certainty,

  33. E.M.Smith says:

    @nessimmersion & pyromancer76:

    Please forgive my being slow to approve your comnents at:

    https://chiefio.wordpress.com/2020/08/01/ivermectin-doxycycline-98-cure/#comment-131769

    https://chiefio.wordpress.com/2020/08/01/ivermectin-doxycycline-98-cure/#comment-131776

    I’d not checked “moderation” for a couple of days…

    @nessimmersion: you r link on HCQ is effective.

    https://c19study.com/

    @pyromancer76:

    Yeah, WUWT has decided no,Younger Dryas impact could be, so touts any “study” saying “no”: Ignores massive evidrnce for “yes”.

  34. A C Osborn says:

    nessimmersion says: 2 August 2020 at 10:44 am
    Re Karl Denniger.
    There is quite a bit wrong with his spiel, first of all many countries have Mortality rates over 10% for COVID-19, some are around 15% and some are even over it. Mostly because they had no prior experince with Pandemics
    Next the Head of the South Korea Pandemic Team stated that Masks were essential, along with gloves and glasses, in addition to hand washing. Because you can catch it via your eyes.
    Now who am I going to believe on this, Mr Denniger or the Head of the Pandemic Team that has succesfully led his team through 3 Pandemics?
    Singapore – 54,254 cases
    South Korea – 14,456 cases

  35. llanfar says:

    I couldn’t find the prior post for measuring Ivermectin (my wife is getting tested this morning; if she has it, I probably have it asymptomatically. My cousin shot me a concise page (including YouTube) last night… https://www.maximpulse.com/permethrin/ivermectin-calculating-a-dose.html

  36. nessimmersion says:

    No apologies required for moderation, it is your blog and time after all.
    I have been geting a lot of references from this site, a good collation of current Covid research and evidence.

    https://swprs.org/a-swiss-doctor-on-covid-19/

    You may well be fully aware of it already, so feel free to remove if I am reposting old knowledge.

  37. jim2 says:

    The apple flavored ivermectin for horses comes in a large syringe with enough to treat a 1250 pound horse. The syringe plunger is calibrated in 250 pound increments for a 200 ul/kg dose. So, it is easy to figure out from your weight in pounds the proper plunger travel. You can mark it on the plunger and dispense the right amount. You can get it at tractor supply.

  38. H.R. says:

    @jim2 – That’s exactly what I bought and I got it at Tractor Supply. What surprised me was that it was only $3.99. It’s cheap!

    The liquid drench is another story. They had various sizes of it in a locked display case and the smallest bottle, just a couple of ounces, was around $30.00. I suppose the liquids are concentrates and that’s the reason they are so high.

    Anyhow, I hope I never find out how tasty the apple flavored Ivermectin actually is :o)

  39. llanfar says:

    @H.R. I bet you couldn’t tell if mixed with peanut butter…

  40. H.R. says:

    Ha! Or ketchup. Ketchup drowns the taste of anything.

    As kids, our philosophy was, put enough ketchup on it and you can choke down anything. That helped us get through to dessert many a time when mom tried something new on us.

  41. llanfar says:

    Question: is Ivermectin effective on its own? In combination with Zinc?

  42. E.M.Smith says:

    The smallest 8 oz. of drench has about 20 people sized doses. So lots in one bottle.

    The drug has a very wide range between minimal effective to causes issues and in farm use is often just poured on by eyeball guess. (The Vet. Dr. Pol, has a gallon jug in his truck. In one episode he just poured an ounce or two on a horse straight from the jug in a rapid slosh…)

    Drugs are usually “weight per kg of patient” so read your tube or bottle and compute. For my drench, it was about 10 ml to 30 ml depending on your size.

    Example human dosing:
    https://www.drugs.com/dosage/ivermectin.html

    Sheep dose is aboul 30 ml drench for 260 lbs. I consider myself a sheep analog. For horse analogs, a 120 lb person will be about 1/10 a horse. I don’t know the size of the horse tubes.

    Ivermectin appears to work alone OK, but you want added zinc anyway to make your immune system work better.

  43. Annie says:

    And do you put the drench on the back of your neck?! As per pour-on?! We do have a small amount for the handful of cattle here.

  44. E.M.Smith says:

    @Annie:

    Any skin will do. When I did it, I just rubbed it on my belly :-)

    Yes, some soaks in through your hand, but that’s what you want anyway….

    IIRC, I used about 10 ml one time and 15 ml another, it covered about a 10 x 10 inch patch of skin. Critters have hair, so that lets the pour and forget work better. No fur, it tends to run off unless spread out thin.

    But a back rub from a partner would work too :-)

    It drys and soaks in in a few minutes.

    Obligatory Disclaimer:

    I am not a doctor. I am not giving medical advice. I am just describing what I did under prior conditions of a failed medical experience and personal desperation. Always start with your M.D. or D.O. first.

  45. p.g.sharrow says:

    I just found out why the “Powers that Be” are so opposed to Hydroxicloroquine/Zinc treatment for Covid-19. If hydroxy is available as a treatment. then an “Emergency use Authorization” can not be used to speed the development and use of an inoculation. This is a matter of law.
    It is also a matter of money…………$Billions of saved development costs and time. Far better that a few hundred thousand people die and the world be thrust into a Depression.

  46. David A Anderson says:

    PG, and the crisis must continue; voting places are very often churches and schools, so what are they exerting a strong effort to keep shut down? ( Yep)

  47. A C Osborn says:

    EM, yet another fix to COVID-19, this time it is Budesomide, anti Asthma treatment given by nebulizer.

  48. Simon Derricutt says:

    Might be useful to check out https://hcqtrial.com/ for an analysis of results of those countries that used HCQ and those that didn’t. A bit hard to pin down precisely, since the WHO said in June that it was dangerous so some countries stopped any trials. Still, overall they’ve tried to get a good correlation.

  49. Annie says:

    Thankyou E. M. Smith. Getting hold of my GP is another matter…she was on one day per week near us and ‘phone only after lockdown. Might just have to look a little further!

  50. cdquarles says:

    Again, be very careful about applying other mammal dose per kilogram to humans. A straight usage may fail due to differing pharmacology (absorption, volume of distribution and/or metabolism). Try to find human data if possible. On the other hand, if the therapeutic window is wide, you may get away with it. The therapeutic window is the difference in the effective dose versus the toxic dose.

  51. cdquarles says:

    Oh, another thing, too. Animal pharmaceuticals often have binders or solvents that differ from those used in human ones. The same caveats apply to them, too; that is, binders and solvents that are not a problem for non-human mammals may be a problem for humans and vice-versa.

  52. E.M.Smith says:

    @CDQuarles:

    Good points.

    Note that I gave a link to human dosing above. That has the risk of different administration routes. Oral vs drench absorption rates and concentrations. That’s what M.D.s do all that training for, to properly calculate that kind of thing.

    What I did with ivermectin drench does not generalize to other drugs, YMMV, proceed with caution and knowing you are accepting risks and personal responsibility.

    The drench I used was Durvet brand for cattle. 5 mg ivermectin per ml. Calculate accordingly.
    Other brands or target species may be different. I knew of this being used (grew up in farm country & Dad had some cattle…) and knew folks spilled on themselves without issues.

    Then, I had a sick bunny problem. E. Cuniculi can kill a whole herd. As there was no known good treatment then, I had to go off-page and pioneer. The result worked, rapidly and well.

    https://chiefio.wordpress.com/2015/06/28/rabbits-e-cuniculi-and-a-rewarding-moment-from-cure/

    In the process of holding a small bunny with neurological issues and applying drench, I had small dose exposure from spills (scared bunnies kick…). So I had a baseline measure of issues before doing anything else.

    When, later, I too got a “problem disease” and medical treatment was a nonop, I again needed to pioneer. My aporoach was very incremental. You DO NOT just jump off off-page cliffs… Started with 1 ml. No Bad Thing. Did 5 ml a few days later. Rubbed on the rash. That spot improved & No Bad Thing. Doubled again to 10 ml. No Bad Thing. On another occasion, I did the 15 ml. dose with No Bad Thing.

    At this point I can confirm that for that drench, a 230 lb. Male had zero side effects from a 15 ml dose. I’ve had more issues from OTC NSAIDS.

    I also did background research on the composition and such. The package insert and my PDR for general ivermectin information. Essentially, the dose varies widely based on target parasite species more than host, with a fairly high dose before issues. The warnings for people were for skin irritation. Most likely from the flamable solvent in it. Smells like mostly alcohol with some other minor solvent to me. I had no skin response to it, so suspect that only shows up after prolonged exposure treating a large herd.

    https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f5aa53ab-2c44-4652-88fc-11bde79dce8d

    I’ve bolded a bit.

    WARNING! NOT FOR USE IN HUMANS
    This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

    Keep this and all drugs out of the reach of children.

    WARNING! FLAMMABLE!

    KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.

    The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, obtain an MSDS, or for assistance call Durvet on 816-229-9101.

    I can’t find the msds for the cattle drench just now, but the sheep one looks similar:

    Click to access DURVETSHEEPDRENCHMSDS.pdf

    Mostly water, propylene glycol, polysorbate, and benzyl alcohol. I think the cattle version has less water and more alcohol for more rapid evaporation.

    In any case, that’s the kind of homework I did before dosing the bunnies, then added the PDR before trying it on me. You must do your homework.

    And yes, I was very anal about it all… I’m like that… but you must look up the solvents used in any drench, so I did. Found the same stuff you read on your bathroom products.

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